Coelho Camila Henriques, Doritchamou Justin Yai Alamou, Zaidi Irfan, Duffy Patrick E
Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA.
NPJ Vaccines. 2017 Nov 30;2:34. doi: 10.1038/s41541-017-0035-3. eCollection 2017.
The Malaria Vaccine Symposium occurred at Johns Hopkins University in Baltimore, MD, USA on April 25th, 2017, coinciding with World Malaria Day and the WHO announcement that the RTS,S malaria vaccine would begin pilot implementation programs in Ghana, Kenya, and Malawi in 2018. Scientists from several disciplines reported progress on an array of malaria vaccine concepts and product candidates, including pre-erythrocytic vaccines that prevent infection, blood-stage vaccines that limit infection and disease, and transmission-blocking vaccines that interrupt the spread of infection. Other speakers highlighted the immunological and genetic considerations that must be addressed by vaccinologists to yield the most efficacious vaccines. Here, we highlight the advances in malaria vaccinology that were reported at the symposium.
2017年4月25日，疟疾疫苗研讨会在美国马里兰州巴尔的摩的约翰·霍普金斯大学举行，恰逢世界疟疾日以及世界卫生组织宣布RTS,S疟疾疫苗将于2018年在加纳、肯尼亚和马拉维启动试点实施项目。来自多个学科的科学家报告了一系列疟疾疫苗概念和候选产品的进展情况，包括预防感染的红细胞前期疫苗、限制感染和疾病的血液阶段疫苗以及阻断感染传播的传播阻断疫苗。其他发言者强调了疫苗学家为研发出最有效的疫苗必须考虑的免疫学和遗传学因素。在此，我们重点介绍研讨会上报告的疟疾疫苗学进展。
