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科学进步尽管不可重现:一个看似矛盾的现象。

Scientific progress despite irreproducibility: A seeming paradox.

机构信息

Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN 47405;

Department of Intelligent Systems Engineering, Indiana University Bloomington, Bloomington, IN 47405.

出版信息

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2632-2639. doi: 10.1073/pnas.1711786114.

DOI:10.1073/pnas.1711786114
PMID:29531095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5856513/
Abstract

It appears paradoxical that science is producing outstanding new results and theories at a rapid rate at the same time that researchers are identifying serious problems in the practice of science that cause many reports to be irreproducible and invalid. Certainly, the practice of science needs to be improved, and scientists are now pursuing this goal. However, in this perspective, we argue that this seeming paradox is not new, has always been part of the way science works, and likely will remain so. We first introduce the paradox. We then review a wide range of challenges that appear to make scientific success difficult. Next, we describe the factors that make science work-in the past, present, and presumably also in the future. We then suggest that remedies for the present practice of science need to be applied selectively so as not to slow progress and illustrate with a few examples. We conclude with arguments that communication of science needs to emphasize not just problems but the enormous successes and benefits that science has brought and is now bringing to all elements of modern society.

摘要

看起来有些矛盾

一方面,科学正在快速产生杰出的新成果和理论;另一方面,研究人员发现科学实践中存在严重问题,导致许多报告无法重现,也失去了有效性。诚然,科学实践需要改进,而科学家们现在正在追求这一目标。然而,从这个角度来看,我们认为这种看似矛盾的现象并不新鲜,它一直是科学运作方式的一部分,而且可能会继续如此。我们首先介绍这个悖论,然后回顾一系列似乎使科学成功变得困难的挑战。接下来,我们描述了过去、现在以及推测未来使科学发挥作用的因素。然后,我们建议有针对性地应用科学实践的补救措施,以免减缓科学发展的步伐,并通过一些例子来说明。最后,我们提出科学传播不仅需要强调问题,还需要强调科学已经带来的巨大成功和益处,以及它现在正给现代社会各个方面带来的益处。

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本文引用的文献

1
The preregistration revolution.预注册革命。
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2600-2606. doi: 10.1073/pnas.1708274114.
2
Crisis or self-correction: Rethinking media narratives about the well-being of science.危机还是自我修正:重新思考媒体对科学福祉的叙事。
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2620-2627. doi: 10.1073/pnas.1708276114.
3
Reproducibility of research: Issues and proposed remedies.研究的可重复性:问题与建议的补救措施。
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2561-2562. doi: 10.1073/pnas.1802324115. Epub 2018 Mar 12.
4
The Changing Landscape of Neuroscience Research, 2006-2015: A Bibliometric Study.2006 - 2015年神经科学研究的变化态势:一项文献计量学研究
Front Neurosci. 2017 Mar 21;11:120. doi: 10.3389/fnins.2017.00120. eCollection 2017.
5
Why the US science and engineering workforce is aging rapidly.为何美国科技和工程劳动力迅速老龄化。
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3879-3884. doi: 10.1073/pnas.1611748114. Epub 2017 Mar 27.
6
Katy Börner: Atlas of science: visualizing what we know: The MIT Press, Cambridge, MA/London, UK, 2010, US$20.凯蒂·博纳:《科学图谱:可视化我们所知的一切》:麻省理工学院出版社,马萨诸塞州剑桥/英国伦敦,2010年,20美元。
Scientometrics. 2011 Aug;88(2):675-677. doi: 10.1007/s11192-011-0409-7. Epub 2011 May 13.
7
Weather modification.人工影响天气
Science. 1973 Aug 31;181(4102):798-800. doi: 10.1126/science.181.4102.798.
8
On the Interpretation of the Markings on Mars.关于火星表面标记的解读
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9
The increasing dominance of teams in production of knowledge.团队在知识生产中日益占据主导地位。
Science. 2007 May 18;316(5827):1036-9. doi: 10.1126/science.1136099. Epub 2007 Apr 12.