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癌症中的葡萄糖代谢：丙酮酸激酶的故事仍在继续。

Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.

机构信息

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

出版信息

Cancer Cell. 2018 Mar 12;33(3):337-339. doi: 10.1016/j.ccell.2018.02.008.

DOI:10.1016/j.ccell.2018.02.008
PMID:29533776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6237085/
Abstract

Altered glucose metabolism is common in cancer. In this issue of Cancer Cell, Morita et al. report new mouse models that express specific isoforms of pyruvate kinase to study glycolysis in tumors. They report several unanticipated findings that challenge current ideas in cancer metabolism.

摘要

葡萄糖代谢改变在癌症中很常见。在本期《癌细胞》杂志上，Morita 等人报告了表达特定丙酮酸激酶同工酶的新小鼠模型，用于研究肿瘤中的糖酵解。他们报告了一些出乎意料的发现，这些发现挑战了癌症代谢领域的现有观点。

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2
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3
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EMBO Rep. 2016 Dec;17(12):1721-1730. doi: 10.15252/embr.201643300. Epub 2016 Nov 17.
4
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