Speziale Pietro, Rindi Simonetta, Pietrocola Giampiero
Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
Department of Industrial and Information Engineering, University of Pavia, 27100 Pavia, Italy.
Microorganisms. 2018 Mar 13;6(1):25. doi: 10.3390/microorganisms6010025.
is a human pathogen that can cause a wide spectrum of diseases, including sepsis, pneumonia, arthritis, and endocarditis. Ineffective treatment of a number of staphylococcal infections with antibiotics is due to the development and spread of antibiotic-resistant strains following decades of antibiotic usage. This has generated renewed interest within the scientific community in alternative therapeutic agents, such as anti- antibodies. Although the role of antibodies in the management of diseases is controversial, the success of this pathogen in neutralizing humoral immunity clearly indicates that antibodies offer the host extensive protection. In this review, we report an update on efforts to develop antibody-based agents, particularly monoclonal antibodies, and their therapeutic potential in the passive immunization approach to the treatment and prevention of infections.
是一种人类病原体，可导致多种疾病，包括败血症、肺炎、关节炎和心内膜炎。由于数十年使用抗生素后抗生素耐药菌株的产生和传播，许多葡萄球菌感染的治疗效果不佳。这使得科学界重新关注替代治疗剂，如抗体。尽管抗体在疾病管理中的作用存在争议，但这种病原体在中和体液免疫方面的成功清楚地表明抗体为宿主提供了广泛的保护。在本综述中，我们报告了开发基于抗体的药物，特别是单克隆抗体的努力的最新情况，以及它们在被动免疫方法治疗和预防感染中的治疗潜力。
