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北欧关于成人可能的重度哮喘系统评估与管理的共识声明。

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults.

作者信息

Porsbjerg Celeste, Ulrik Charlotte, Skjold Tina, Backer Vibeke, Laerum Birger, Lehman Sverre, Janson Crister, Sandstrøm Thomas, Bjermer Leif, Dahlen Barbro, Lundbäck Bo, Ludviksdottir Dora, Björnsdóttir Unnur, Altraja Alan, Lehtimäki Lauri, Kauppi Paula, Karjalainen Jussi, Kankaanranta Hannu

机构信息

Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Respiratory Research unit, Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Eur Clin Respir J. 2018 Mar 6;5(1):1440868. doi: 10.1080/20018525.2018.1440868. eCollection 2018.

Abstract

Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma ('difficult asthma') should undergo systematic assessment, in order to differentiate between true severe asthma, and 'difficult-to-treat' patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

摘要

虽然少数哮喘患者患有重度哮喘,但他们在临床上面临着重大挑战,即尽管接受了高剂量治疗,症状控制仍不佳,存在病情加重风险和副作用。新型生物治疗可能使重度哮喘患者受益,但费用高昂,且仅对目标明确的患者有效。在一些患者中,症状由哮喘以外的其他因素驱动,所有疑似重度哮喘(“难治性哮喘”)的患者都应接受系统评估,以区分真正的重度哮喘和“难治性”患者,后者控制不佳与依从性差或合并症等因素有关。北欧重度哮喘共识声明由北欧重度哮喘网络制定,该网络成员来自挪威、瑞典、芬兰、丹麦、冰岛和爱沙尼亚,包括各国呼吸科学协会的代表,旨在提供有关重度哮喘诊断、系统评估和管理的概述及建议。此外,该共识声明还针对初级、二级和三级护理中重度哮喘管理的组织提出了建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88cb/5844041/1564969f630a/ZECR_A_1440868_F0001_C.jpg

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