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青少年肠道微生物群与脂肪肝的关系：EPOCH 研究。

Gut microbiota in adolescents and the association with fatty liver: the EPOCH study.

机构信息

Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA.

Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

出版信息

Pediatr Res. 2018 Aug;84(2):219-227. doi: 10.1038/pr.2018.32. Epub 2018 Apr 18.

DOI:10.1038/pr.2018.32
PMID:29538359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6185796/
Abstract

BACKGROUND

Recent evidence supports that the gut microbiota may be involved in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), and may also offer avenues for treatment or prevention.

METHODS

We investigated the associations among gut microbiota, diet, and hepatic fat fraction (HFF) in 107 adolescents. Magnetic resonance imaging (MRI) was used to assess HFF, and 16S rRNA gene sequencing was performed on collected fecal samples. Dietary intake was assessed using Food Frequency Questionnaires. We examined the association between gut microbiota alpha diversity and HFF, and assessed the predictive accuracy for HFF of (1) taxonomic composition, (2) dietary intake, (3) demographic and comorbid conditions, and (4) the combination of these.

RESULTS

Lower alpha diversity was associated with higher HFF (β=-0.19, 95% confidence interval (CI) -0.36, -0.02). The selected taxa explained 17.7% (95% CI: 16.0-19.4%) of the variation in HFF. The combination of two of these taxa, Bilophila and Paraprevotella, with dietary intake of monounsaturated fatty acids and BMI z-scores explained 32.0% (95% CI: 30.3-33.6%) of the variation in HFF.

CONCLUSION

The gut microbiota is associated with HFF in adolescents and may be useful to help identify youth who would be amenable to gut microbiota-based interventions.

摘要

背景

最近的证据表明，肠道微生物群可能参与非酒精性脂肪性肝病（NAFLD）的病理生理学，并且可能为治疗或预防提供途径。

方法

我们调查了 107 名青少年的肠道微生物群、饮食和肝脂肪分数（HFF）之间的关联。磁共振成像（MRI）用于评估 HFF，收集的粪便样本进行 16S rRNA 基因测序。使用食物频率问卷评估饮食摄入。我们检查了肠道微生物群 alpha 多样性与 HFF 之间的关联，并评估了（1）分类组成、（2）饮食摄入、（3）人口统计学和合并症状况以及（4）这些因素的组合对 HFF 的预测准确性。

结果

较低的 alpha 多样性与较高的 HFF 相关（β=-0.19，95%置信区间（CI）-0.36，-0.02）。所选分类群解释了 HFF 变化的 17.7%（95%CI：16.0-19.4%）。这两个分类群（Bilophila 和 Paraprevotella）与单不饱和脂肪酸和 BMI z 评分的饮食摄入的组合解释了 HFF 变化的 32.0%（95%CI：30.3-33.6%）。

结论

肠道微生物群与青少年的 HFF 相关，可能有助于识别适合基于肠道微生物群的干预的年轻人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/1ac544969551/nihms943761f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/1ace03252962/nihms943761f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/513f75aec03d/nihms943761f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/1ac544969551/nihms943761f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/1ace03252962/nihms943761f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/513f75aec03d/nihms943761f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a488/6185796/1ac544969551/nihms943761f3.jpg

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