Ramirez-Garcia Andoni, Pellon Aize, Rementeria Aitor, Buldain Idoia, Barreto-Bergter Eliana, Rollin-Pinheiro Rodrigo, de Meirelles Jardel Vieira, Xisto Mariana Ingrid D S, Ranque Stephane, Havlicek Vladimir, Vandeputte Patrick, Govic Yohann Le, Bouchara Jean-Philippe, Giraud Sandrine, Chen Sharon, Rainer Johannes, Alastruey-Izquierdo Ana, Martin-Gomez Maria Teresa, López-Soria Leyre M, Peman Javier, Schwarz Carsten, Bernhardt Anne, Tintelnot Kathrin, Capilla Javier, Martin-Vicente Adela, Cano-Lira Jose, Nagl Markus, Lackner Michaela, Irinyi Laszlo, Meyer Wieland, de Hoog Sybren, Hernando Fernando L
Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil.
Med Mycol. 2018 Apr 1;56(suppl_1):102-125. doi: 10.1093/mmy/myx113.
Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
赛多孢属和洛蒙孢属真菌被视为新兴的机会致病菌，可感染免疫抑制及其他身体虚弱的患者，尽管传统上已知它们会在健康个体中引起与创伤相关的感染。临床表现从局部感染到肺部定植以及严重的侵袭性疾病不等，其中死亡率可能超过80%。这些高得令人无法接受的死亡率是由于患者的临床状况、诊断困难以及这些真菌固有的抗真菌耐药性。因此，已经成立了几个联盟来加大对这些罕见真菌的研究力度。本综述介绍了最近的研究结果，并总结了最相关的要点，包括赛多孢属/洛蒙孢属的分类学、环境分布、流行病学、病理学、毒力因子、免疫学、诊断方法和治疗策略。
