State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu, 610065, China.
Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Key Laboratory of Disease Proteomics of Chongqing, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110833. doi: 10.1016/j.msec.2020.110833. Epub 2020 Mar 10.
In order to obtain a novel multifunctional wound dressing with good water vapor permeability and long-lasting antibacterial properties, a skin-like thermoplastic polyurethane (TPU) bilayer membrane containing self-made polyhexamethylene guanidine hydrochloride (PHMG) grafted graphene oxide (MGO) was prepared by non-solvent phase separation and particle filtration. The antibacterial properties and wound-healing ability of TPU, GO-TPU, MGO-TPU composite porous membrane are systematically compared. The results show that with the incorporation of MGO, the porous MGO-TPU membrane exhibits good biocompatibility, excellent water vapor transmission properties, and long-lasting broad-spectrum antibacterial properties (the antibacterial property remains unchanged for 30 days under continuously shaking and washing). The wound healing results for mouse model show that MGO-TPU could significantly accelerate the healing rate of wounds as it provides a sterile environment and also promotes the formation of re-epithelialization during wound healing.
为了获得一种具有良好水蒸气透过率和持久抗菌性能的新型多功能伤口敷料，采用非溶剂相分离和颗粒过滤法制备了一种含有自制盐酸聚六亚甲基胍（PHMG）接枝氧化石墨烯（MGO）的仿人皮热塑性聚氨酯（TPU）双层膜。系统比较了 TPU、GO-TPU、MGO-TPU 复合多孔膜的抗菌性能和伤口愈合能力。结果表明，随着 MGO 的加入，多孔 MGO-TPU 膜表现出良好的生物相容性、优异的水蒸气透过性能和持久的广谱抗菌性能（在连续振荡和洗涤下 30 天内抗菌性能保持不变）。对小鼠模型的伤口愈合结果表明，MGO-TPU 能够显著加快伤口愈合速度，因为它提供了无菌环境，并在伤口愈合过程中促进再上皮化的形成。
