Shi Guang, Zhao Jun-Wei, Sun Xiao-Xu, Ma Jun-Fen, Wang Pan, He Fu-Cheng, Ming Liang
Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Key Clinical Laboratory of Henan Province, Zhengzhou, Henan 450052, P.R. China.
Exp Ther Med. 2018 Apr;15(4):3449-3454. doi: 10.3892/etm.2018.5870. Epub 2018 Feb 14.
The interaction between inflammatory processes and a hypercoagulant state may aggravate the severity of asthma and stimulate the airway remodeling of asthma. The aim of the current study was to evaluate the association between the negative inflammatory regulator tumor necrosis factor α induced protein-8 like-2 (TIPE2) and the coagulating substances tissue factor (TF) and thrombospondin-1 (TSP-1) in patients with bronchial asthma. Compared with healthy controls, TIPE2 expression was significantly downregulated, whereas TF expression was upregulated in the peripheral blood mononuclear cells (PBMCs) of patients with bronchial asthma. In addition, levels of TF and TSP-1 in the sera were up-regulated in patients with asthma compared with healthy controls. TIPE2 expression was negatively correlated with TF in the PBMCs and sera and was negatively correlated with TSP-1 levels in the sera of patients with bronchial asthma. The results of the current study indicated that anti-inflammatory TIPE2 levels are associated with levels of the coagulation substances TF and TSP-1. However, further studies are required to determine whether TIPE2 participates in the pathogenesis of asthma by interacting with the coagulation substances TF and TSP-1.
炎症过程与高凝状态之间的相互作用可能会加重哮喘的严重程度，并刺激哮喘的气道重塑。本研究的目的是评估支气管哮喘患者中负性炎症调节因子肿瘤坏死因子α诱导蛋白8样蛋白2（TIPE2）与凝血物质组织因子（TF）和血小板反应蛋白1（TSP-1）之间的关联。与健康对照相比，支气管哮喘患者外周血单个核细胞（PBMCs）中TIPE2表达显著下调，而TF表达上调。此外，与健康对照相比，哮喘患者血清中TF和TSP-1水平上调。支气管哮喘患者PBMCs和血清中TIPE2表达与TF呈负相关，且与血清中TSP-1水平呈负相关。本研究结果表明，抗炎性TIPE2水平与凝血物质TF和TSP-1的水平相关。然而，需要进一步研究以确定TIPE2是否通过与凝血物质TF和TSP-1相互作用参与哮喘的发病机制。
