Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo 21, 00128 Rome, Italy.
Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo 21, 00128 Rome, Italy.
Cancer Lett. 2018 Jun 1;423:139-146. doi: 10.1016/j.canlet.2018.03.011. Epub 2018 Mar 13.
In the last two decades, white adipose tissue (WAT) has been recognized as a key actor of many physiological and pathological conditions. WAT is able to produce mediators, named "adipokines", which may affect systemic homeostasis. In particular, leptin is not only involved in appetite and energy metabolism, but also in immune system. Increasing evidence established that leptin can regulate both innate and adaptive immunity mainly with pro-inflammatory effects but also, to a lesser extent, with anti-inflammatory features. In autoimmune diseases, a failure or breakdown of the mechanisms of self-tolerance is observed. Leptin, which plays an important role in the control of immune balance, has been involved in autoimmunity generation and maintenance. In this review, it has been provided an up-to-date report about the role of leptin in systemic autoimmune diseases, with particular reference to connective tissue diseases, inflammatory arthritis, and vasculitis.
在过去的二十年中，白色脂肪组织 (WAT) 已被认为是许多生理和病理状况的关键因素。WAT 能够产生被称为“脂肪因子”的介质，这些介质可能会影响全身的稳态。特别是，瘦素不仅参与食欲和能量代谢，还参与免疫系统。越来越多的证据表明，瘦素主要通过促炎作用，但在较小程度上通过抗炎作用来调节先天和适应性免疫。在自身免疫性疾病中，观察到自身耐受机制的失败或崩溃。在免疫平衡的控制中起重要作用的瘦素已参与自身免疫的产生和维持。在这篇综述中，提供了关于瘦素在系统性自身免疫性疾病中的作用的最新报告，特别参考了结缔组织疾病、炎性关节炎和血管炎。
