Härmälä Suvi, Parisinos Constantinos, Shallcross Laura, O'Brien Alastair, Hayward Andrew
Institute of Health Informatics, University College London, London, UK.
Division of Medicine, University College London, London, UK.
BMJ Open. 2018 Mar 16;8(3):e018223. doi: 10.1136/bmjopen-2017-018223.
In advanced chronic liver disease, diseases caused by common bacteria or influenza virus put people at an increased risk of serious health complications and death. The effectiveness of the available vaccines in reducing the risk of poor health outcomes, however, is less clear.
We will search Medline (Ovid), Embase (Ovid), PubMed and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of pneumococcal and influenza vaccines in people with chronic liver disease. Two independent reviewers will screen the studies for eligibility, extract data and assess study quality and risk of bias. Random effects meta-analyses will be performed as appropriate.
Formal ethical approval is not required, as no primary data will be collected for this study. We will publish results of this study in relevant peer-reviewed medical journal or journals. Where possible, the study results will also be presented as posters or talks at relevant medical conferences and meetings.
CRD42017067277.
在晚期慢性肝病中，由常见细菌或流感病毒引起的疾病会使人们面临严重健康并发症和死亡的风险增加。然而，现有疫苗在降低健康不良后果风险方面的有效性尚不清楚。
我们将检索Medline（Ovid）、Embase（Ovid）、PubMed和Cochrane对照试验中央注册库，以获取关于肺炎球菌疫苗和流感疫苗对慢性肝病患者有效性的随机对照试验和观察性研究的已发表报告。两名独立评审员将筛选研究的 eligibility，提取数据并评估研究质量和偏倚风险。将酌情进行随机效应荟萃分析。
由于本研究不会收集原始数据，因此无需正式的伦理批准。我们将在相关的同行评审医学期刊上发表本研究的结果。如有可能，研究结果还将以海报形式展示或在相关医学会议上进行汇报。
PROSPERO注册号：CRD42017067277。 （注：原文中“eligibility”未准确翻译，可结合上下文理解其准确意思）
