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本文引用的文献

1
Prospective Study of Epigenetic Age Acceleration and Incidence of Cardiovascular Disease Outcomes in the ARIC Study (Atherosclerosis Risk in Communities).前瞻性研究表观遗传年龄加速与心血管疾病结局在 ARIC 研究中的发生（社区动脉粥样硬化风险）。
Circ Genom Precis Med. 2018 Mar;11(3):e001937. doi: 10.1161/CIRCGEN.117.001937.
2
GWAS of epigenetic aging rates in blood reveals a critical role for TERT.血液表观遗传衰老速度的全基因组关联研究揭示了 TERT 的关键作用。
Nat Commun. 2018 Jan 26;9(1):387. doi: 10.1038/s41467-017-02697-5.
3
Methylation-based estimated biological age and cardiovascular disease.基于甲基化的生物年龄估算与心血管疾病。
Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12872. Epub 2017 Dec 27.
4
Leukocyte telomere length, T cell composition and DNA methylation age.白细胞端粒长度、T细胞组成与DNA甲基化年龄。
Aging (Albany NY). 2017 Sep 20;9(9):1983-1995. doi: 10.18632/aging.101293.
5
Forensic individual age estimation with DNA: From initial approaches to methylation tests.基于DNA的法医个体年龄估计：从最初的方法到甲基化测试
Forensic Sci Rev. 2017 Jul;29(2):121-144.
6
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.饮食限制可预防与年龄相关的DNA甲基化，并诱导脂质代谢的表观遗传重编程。
Genome Biol. 2017 Mar 28;18(1):56. doi: 10.1186/s13059-017-1187-1.
7
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.饮食、运动、教育和生活方式因素的表观遗传时钟分析。
Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168.
8
DNA methylation-based measures of biological age: meta-analysis predicting time to death.基于DNA甲基化的生物学年龄测量方法：预测死亡时间的荟萃分析。
Aging (Albany NY). 2016 Sep 28;8(9):1844-1865. doi: 10.18632/aging.101020.
9
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.种族/民族、性别与冠心病的表观遗传时钟分析
Genome Biol. 2016 Aug 11;17(1):171. doi: 10.1186/s13059-016-1030-0.
10
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort.表观遗传年龄加速可预测德国病例队列中的癌症、心血管疾病及全因死亡率。
Clin Epigenetics. 2016 Jun 3;8:64. doi: 10.1186/s13148-016-0228-z. eCollection 2016.

Epigenetic Age Acceleration: A Biological Doomsday Clock for Cardiovascular Disease?

作者信息

Mendelson Michael M

机构信息

From the Department of Cardiology, Boston Children's Hospital, Harvard Medical School, MA.

出版信息

Circ Genom Precis Med. 2018 Mar;11(3):e002089. doi: 10.1161/CIRCGEN.118.002089.

DOI:10.1161/CIRCGEN.118.002089
PMID:29555673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5870129/
Abstract
摘要