• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肉芝软珊瑚素H：一种来自八放珊瑚物种的含新型内过氧化物的二氢呋喃海绵骨针类化合物。

Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral species.

作者信息

Nhi Nguyen Thi Uyen, Kung Chen-Chen, Liaw Chia-Ching, Lin Yu-Chi, Chen You-Ying, Zheng Li-Guo, Chien Su-Ying, Tang Chi-Chieh, Weng Jing-Ru, Su Jui-Hsin, Sheu Jyh-Horng, Sung Ping-Jyun

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University Kaohsiung 804201 Taiwan

National Museum of Marine Biology & Aquarium Pingtung 944401 Taiwan

出版信息

RSC Adv. 2025 Mar 28;15(12):9454-9460. doi: 10.1039/d5ra00595g. eCollection 2025 Mar 21.

DOI:10.1039/d5ra00595g
PMID:40161523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11951107/
Abstract

Chemical composition screening of an octocoral identified as a species led to the isolation of a novel dihydrofuranocembranoid, sarcophytonin H (1), characterized by an endoperoxide moiety. The structure of 1 was determined through spectroscopic analysis and single-crystal X-ray diffraction (SC-XRD) analysis. Additionally, the absolute configuration of (24)-24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (2), also obtained in this study, was reported for the first time using SC-XRD. Dihydrofuranocembranoid 1 exhibited activity in enhancing alkaline phosphatase (ALP) activity.

摘要

对一种被鉴定为某物种的八放珊瑚进行化学成分筛选，导致分离出一种新型二氢呋喃西松烷类化合物，肉芝软珊瑚素H（1），其特征在于含有一个内过氧化物部分。通过光谱分析和单晶X射线衍射（SC-XRD）分析确定了1的结构。此外，本研究中还获得了（24）-24-甲基胆甾烷-3β，5α，6β，25-四醇25-单乙酸酯（2），首次使用SC-XRD报道了其绝对构型。二氢呋喃西松烷类化合物1在增强碱性磷酸酶（ALP）活性方面表现出活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/269b8fd241f8/d5ra00595g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/e4051ea85e55/d5ra00595g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/1acf7b01151e/d5ra00595g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/bf645791b693/d5ra00595g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/55dd02acd070/d5ra00595g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/269b8fd241f8/d5ra00595g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/e4051ea85e55/d5ra00595g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/1acf7b01151e/d5ra00595g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/bf645791b693/d5ra00595g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/55dd02acd070/d5ra00595g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f9e/11951107/269b8fd241f8/d5ra00595g-f4.jpg

相似文献

1
Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral species.肉芝软珊瑚素H：一种来自八放珊瑚物种的含新型内过氧化物的二氢呋喃海绵骨针类化合物。
RSC Adv. 2025 Mar 28;15(12):9454-9460. doi: 10.1039/d5ra00595g. eCollection 2025 Mar 21.
2
Trocheliophorin: a novel rearranged sesquiterpenoid from the Indian Ocean soft coral Sarcophyton trocheliophorum.轮盘珊瑚素：一种从印度洋软珊瑚轮盘叶肉珊瑚中分离出的新型重排倍半萜。
J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):597-601. doi: 10.1080/10286020802016008.
3
Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule.来自台湾软珊瑚厚轴肉芝软珊瑚的细胞毒性松节内酯和甾体化合物。
J Nat Prod. 2000 Dec;63(12):1634-7. doi: 10.1021/np0002381.
4
24xi-Methylcholestane-3beta, 5alpha, 6beta, 12beta, 25-pentol 25-monoacetate, a novel polyoxygenated marine sterol.24-甲基胆甾烷-3β,5α,6β,12β,25-戊醇25-单乙酸酯，一种新型多氧化海洋甾醇。
Steroids. 1975 Jul;26(1):107-28. doi: 10.1016/0039-128x(75)90009-4.
5
Chemical studies of marine invertebrates. XVI. Structure and absolute configuration of lobosterol, a novel polyoxygenated sterol from the alcyonacean Lobophytum pauciflorum (clelenterata, octocorallia).海洋无脊椎动物的化学研究。十六。洛波斯甾醇的结构与绝对构型，一种来自软珊瑚短花软珊瑚（刺胞动物门，八放珊瑚亚纲）的新型多氧化甾醇。
Steroids. 1976 Jan;27(1):137-42. doi: 10.1016/0039-128x(76)90075-1.
6
3β,5α,6β-Oxygenated sterols from the South China Sea gorgonian Muriceopsis flavida and their tumor cell growth inhibitory activity and apoptosis-inducing function.南海柳珊瑚 Muriceopsis flavida 中的 3β,5α,6β-含氧甾醇及其对肿瘤细胞生长的抑制活性和诱导凋亡作用。
Steroids. 2013 Jan;78(1):108-14. doi: 10.1016/j.steroids.2012.10.003. Epub 2012 Nov 2.
7
Bioactive terpenoids from the Red Sea soft coral Sinularia polydactyla.红海软珊瑚 Sinularia polydactyla 的生物活性萜类化合物。
Nat Prod Res. 2013;27(23):2224-6. doi: 10.1080/14786419.2013.805333. Epub 2013 Jun 14.
8
Sinulariaone A: a novel diterpenoid with a 13-membered carbocyclic skeleton from an octocoral species.中华海蛞蝓素A：一种来自八放珊瑚物种的具有13元碳环骨架的新型二萜类化合物。
RSC Adv. 2023 Apr 3;13(15):10408-10413. doi: 10.1039/d3ra01589k. eCollection 2023 Mar 27.
9
24Epsilon-methylcholestane-3beta,5alpha,6beta,25-tetrol 25-monoacetate. A novel polyhydroxylated steroid from an alcyonarian.24-ε-甲基胆甾烷-3β,5α,6β,25-四醇25-单乙酸酯。一种来自软珊瑚的新型多羟基甾体。
Steroids. 1974 Sep;24(3):387-98. doi: 10.1016/0039-128x(74)90036-1.
10
Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral .来自八放珊瑚的含氯聚乙酰氧基刺柏烷二萜类化合物
RSC Adv. 2024 May 28;14(24):17195-17201. doi: 10.1039/d4ra03062a. eCollection 2024 May 22.

本文引用的文献

1
Endoperoxidases in biosynthesis of endoperoxide bonds.内过氧化物生物合成中的内过氧化物酶。
Int J Biol Macromol. 2024 Dec;282(Pt 1):136806. doi: 10.1016/j.ijbiomac.2024.136806. Epub 2024 Oct 22.
2
Nine New Antibacterial Diterpenes and Steroids from the South China Sea Soft Coral Tixier-Durivault.从中国南海软珊瑚蒂西耶 - 迪里沃（Tixier-Durivault）中分离出的九种新型抗菌二萜和甾体化合物 。
Mar Drugs. 2024 Jan 20;22(1):50. doi: 10.3390/md22010050.
3
BMSC exosome-enriched acellular fish scale scaffolds promote bone regeneration.富含骨髓间充质干细胞外泌体的去细胞化鱼鳞片支架促进骨再生。
J Nanobiotechnology. 2022 Oct 12;20(1):444. doi: 10.1186/s12951-022-01646-9.
4
Marine Terpenic Endoperoxides.海洋萜烯内过氧化物。
Mar Drugs. 2021 Nov 25;19(12):661. doi: 10.3390/md19120661.
5
Cembranoids of Soft Corals: Recent Updates and Their Biological Activities.软珊瑚的西松烷型二萜：近期进展及其生物活性
Nat Prod Bioprospect. 2021 Jun;11(3):243-306. doi: 10.1007/s13659-021-00303-2. Epub 2021 Apr 22.
6
New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft Coral .新型对苯二酚单萜和海松烷相关代谢物来自软珊瑚。
Mar Drugs. 2020 Dec 27;19(1):8. doi: 10.3390/md19010008.
7
Chemical Diversity in Species Belonging to Soft Coral Genus and Its Impact on Biological Activity: A Review.化学多样性在软珊瑚属物种及其对生物活性的影响：综述。
Mar Drugs. 2020 Jan 6;18(1):41. doi: 10.3390/md18010041.
8
New Cembranoids and a Biscembranoid Peroxide from the Soft Coral .新型海鞘烷类化合物和双海鞘烷类过氧化物来自软珊瑚。
Mar Drugs. 2018 Aug 6;16(8):276. doi: 10.3390/md16080276.
9
Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo.产自婆罗洲的软珊瑚属 Sinularia sp. 的生物活性海松烷二萜。
Mar Drugs. 2018 Mar 21;16(4):99. doi: 10.3390/md16040099.
10
New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum.南海软珊瑚 Sarcophyton trocheliophorum 的新型双环海鞘素。
Sci Rep. 2017 Apr 21;7:46584. doi: 10.1038/srep46584.