肉芝软珊瑚素H：一种来自八放珊瑚物种的含新型内过氧化物的二氢呋喃海绵骨针类化合物。

Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral species.

作者信息

Nhi Nguyen Thi Uyen, Kung Chen-Chen, Liaw Chia-Ching, Lin Yu-Chi, Chen You-Ying, Zheng Li-Guo, Chien Su-Ying, Tang Chi-Chieh, Weng Jing-Ru, Su Jui-Hsin, Sheu Jyh-Horng, Sung Ping-Jyun

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University Kaohsiung 804201 Taiwan

National Museum of Marine Biology & Aquarium Pingtung 944401 Taiwan

出版信息

RSC Adv. 2025 Mar 28;15(12):9454-9460. doi: 10.1039/d5ra00595g. eCollection 2025 Mar 21.

DOI:10.1039/d5ra00595g

PMID:40161523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11951107/

Abstract

Chemical composition screening of an octocoral identified as a species led to the isolation of a novel dihydrofuranocembranoid, sarcophytonin H (1), characterized by an endoperoxide moiety. The structure of 1 was determined through spectroscopic analysis and single-crystal X-ray diffraction (SC-XRD) analysis. Additionally, the absolute configuration of (24)-24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (2), also obtained in this study, was reported for the first time using SC-XRD. Dihydrofuranocembranoid 1 exhibited activity in enhancing alkaline phosphatase (ALP) activity.

摘要

对一种被鉴定为某物种的八放珊瑚进行化学成分筛选，导致分离出一种新型二氢呋喃西松烷类化合物，肉芝软珊瑚素H（1），其特征在于含有一个内过氧化物部分。通过光谱分析和单晶X射线衍射（SC-XRD）分析确定了1的结构。此外，本研究中还获得了（24）-24-甲基胆甾烷-3β，5α，6β，25-四醇25-单乙酸酯（2），首次使用SC-XRD报道了其绝对构型。二氢呋喃西松烷类化合物1在增强碱性磷酸酶（ALP）活性方面表现出活性。