Aljabali Alaa A A, Akkam Yazan, Al Zoubi Mazhar Salim, Al-Batayneh Khalid M, Al-Trad Bahaa, Abo Alrob Osama, Alkilany Alaaldin M, Benamara Mourad, Evans David J
Faculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan.
Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan.
Nanomaterials (Basel). 2018 Mar 19;8(3):174. doi: 10.3390/nano8030174.
(1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expensive and employ chemicals that are potentially harmful to the environment, which calls for the development of "greener" protocols. Herein we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, efficient, inexpensive, and environmentally friendly method to produce well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present in the aqueous leaf extract acted as an effective reducing agent. The generated AuNPs were characterized by Transmission electron microscopy (TEM), Scanning electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared nanoparticles were found to be biocompatible and exhibited no antimicrobial or antifungal effect, deeming the particles safe for various applications in nanomedicine. TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents.
(1) 背景：开发新型纳米颗粒合成方法的需求日益增长。对这类颗粒的关注引发了对其生产方法环境安全性的担忧；(2) 目标：当前纳米颗粒生产方法往往成本高昂且使用可能对环境有害的化学品，这就需要开发“更绿色”的方案。在此，我们描述了使用植物提取物合成金纳米颗粒（AuNPs）的方法，该方法为生产具有明确几何形状的纳米颗粒提供了一种替代、高效、廉价且环保的途径；(3) 方法：水相叶提取物中存在的植物化学物质作为有效的还原剂。通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）、原子力显微镜（AFM）、X射线衍射（XRD）、紫外可见光谱、能量色散X射线（EDX）和热重分析（TGA）对生成的AuNPs进行表征；(4) 结果与结论：所制备的纳米颗粒具有生物相容性，且未表现出抗菌或抗真菌作用，这表明这些颗粒在纳米医学的各种应用中是安全的。TGA分析表明，植物提取物中存在的生物分子包覆了纳米颗粒并起到稳定剂的作用。
