Julkunen Anna, Heikkinen Anna Maria, Söder Birgitta, Söder Per-Östen, Toppila-Salmi Sanna, Meurman Jukka H
Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland.
Department of Dental Medicine, Karolinska Institutet, BOX 4064, 14104 Huddinge, Stockholm, Sweden.
Dent J (Basel). 2017 Dec 22;6(1):1. doi: 10.3390/dj6010001.
Oral infections up-regulate a number of systemic inflammatory reactions that, in turn, play a role in the development of systemic diseases. We investigated the association between oral health and autoimmune diseases in a cohort of Swedish adults. Hypothesis was that poor oral health associates with incidence of autoimmune diseases. Overall 1676 subjects aged 30-40 years old from Stockholm County (Sweden) participated in this study in 1985. Subjects were randomly selected from the registry file of Stockholm region and were followed-up for 30 years. Their hospital and open health care admissions (World Health Organization ICD 9 and 10 codes) were recorded from the Swedish national health registers. The association between the diagnosed autoimmune disease and the oral health variables were statistically analyzed. In all, 50 patients with autoimmune diagnoses were detected from the data. Plaque index was significantly higher in the autoimmune disease group (≥median 35 (70%) vs. ˂median 872 (54%), = 0.030). No statistical difference was found in gingival index, calculus index, missing teeth, periodontal pockets, smoking or snuff use between patients with and without autoimmune disease. Our study hypothesis was partly confirmed. The result showed that subjects with a higher plaque index, marker of poor oral hygiene, were more likely to develop autoimmune diseases in 30 years.
口腔感染会上调多种全身性炎症反应，而这些炎症反应反过来又在全身性疾病的发展中发挥作用。我们在一组瑞典成年人中调查了口腔健康与自身免疫性疾病之间的关联。假设是口腔健康状况差与自身免疫性疾病的发病率相关。1985年，来自瑞典斯德哥尔摩县的1676名年龄在30至40岁之间的受试者参与了这项研究。受试者是从斯德哥尔摩地区的登记档案中随机选取的，并进行了30年的随访。他们的医院就诊和开放式医疗保健就诊情况（世界卫生组织国际疾病分类第9版和第10版代码）从瑞典国家健康登记处记录。对确诊的自身免疫性疾病与口腔健康变量之间的关联进行了统计分析。从数据中总共检测出50例自身免疫性疾病诊断患者。自身免疫性疾病组的菌斑指数显著更高（≥中位数35（70%）对˂中位数872（54%），P = 0.030）。在有无自身免疫性疾病的患者之间，牙龈指数、牙石指数、缺牙情况、牙周袋、吸烟或使用鼻烟方面未发现统计学差异。我们的研究假设得到了部分证实。结果表明，菌斑指数较高（口腔卫生差的标志）的受试者在30年内更有可能患自身免疫性疾病。
