使用眼前节光学相干断层扫描技术对角膜混浊进行客观量化。
Objective quantification of corneal haziness using anterior segment optical coherence tomography.
作者信息
Rose Jeyanth Suresh, Eldrina Juliet, Joshua Aarwin, Amalan S, Sebastian Tunny, Solomon Satheesh, Korah Sanita
机构信息
Department of Ophthalmology, Christian Medical College, Vellore, India.
Center for Stem Cell Research, Christian Medical College, Vellore, India.
出版信息
J Curr Ophthalmol. 2017 Sep 1;30(1):54-57. doi: 10.1016/j.joco.2017.08.001. eCollection 2018 Mar.
PURPOSE
To quantify normal corneal transparency by anterior segment optical coherence tomography (AS-OCT) by measuring the average pixel intensity. To analyze the variation in the average pixel intensity in mild and severe grades of corneal opacities.
METHODS
This is an observational, cross-sectional study of 38 eyes from 19 patients with mild or severe grades of corneal opacities greater than 3 mm and a normal contralateral cornea. AS-OCT was performed centered on the opacity with a 3 mm cruciate protocol. A similar image is taken of the contralateral clear cornea in the same quadrant. The average pixel intensity was calculated in a standardized manner using MATLAB software.
RESULT
The average pixel intensity of the normal cornea was 99.6 ± 10.9 [standard deviation (SD)]. The average pixel intensity of the mild and severe corneal opacities was 115.5 ± 9.1 and 141.1 ± 10.3, respectively. The differences were statistically significant.
CONCLUSIONS
AS-OCT images can be used to quantify corneal transparency. Average pixel intensity is a measure that varies significantly with varying corneal opacification.
目的
通过测量平均像素强度，利用眼前节光学相干断层扫描（AS-OCT）对正常角膜透明度进行量化。分析轻度和重度角膜混浊患者平均像素强度的变化情况。
方法
这是一项观察性横断面研究，纳入了19例角膜混浊程度为轻度或重度（混浊范围大于3mm）的患者的38只眼，对侧角膜正常。采用3mm十字形扫描方案，以混浊部位为中心进行AS-OCT检查。在同一象限对侧透明角膜拍摄类似图像。使用MATLAB软件以标准化方式计算平均像素强度。
结果
正常角膜的平均像素强度为99.6±10.9[标准差（SD）]。轻度和重度角膜混浊的平均像素强度分别为115.5±9.1和141.1±10.3。差异具有统计学意义。
结论
AS-OCT图像可用于量化角膜透明度。平均像素强度是一种随角膜混浊程度变化而有显著差异的测量指标。
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