Division of Basic Medical Science, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan.
Institute of Biochemistry, Microbiology and Immunology, Chung-Shan Medical University, Number 110, Section 1, Jianguo North Road, Taichung 402, Taiwan.
J Food Drug Anal. 2018 Apr;26(2):778-787. doi: 10.1016/j.jfda.2017.10.008. Epub 2017 Dec 2.
Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are regulated by the leptin and adiponectin. MLE could prevent obesity-related NAFLD via downregulating the lipogenesis enzymes while upregulating the lipolysis markers. Treatment of MLE, especially at 2%, enhanced the expression of superoxide dismutase (SOD) and clenched the oxidative stress of liver. MLE decreased the plasma level of leptin but increased adiponectin. The advantage of MLE is supposed mainly attributed to chlorogenic acid derivative. We suggest MLE, with promising outcome of research, could be nutraceutical to prevent obesity and related NAFLD.
桑叶在中医中被用作治疗高血脂和代谢紊乱的药物。最近的报告表明，桑叶提取物（MLE）可减轻高脂肪饮食（HFD）喂养的小鼠的血脂异常和脂质积累。非酒精性脂肪肝（NAFLD）通常被认为是代谢综合征的肝脏成分。肝脂质浸润会引起氧化应激，与白细胞介素 6（IL-6）和肿瘤坏死因子-α（TNF-α）有关，这些因子受瘦素和脂联素的调节。MLE 通过下调脂肪生成酶和上调脂肪分解标志物来预防与肥胖相关的 NAFLD。MLE 的治疗，特别是在 2%的浓度下，增强了超氧化物歧化酶（SOD）的表达，并抑制了肝脏的氧化应激。MLE 降低了血浆瘦素水平，但增加了脂联素。MLE 的优势主要归因于绿原酸衍生物。我们建议，具有良好研究结果的 MLE 可能是一种预防肥胖和相关 NAFLD 的营养保健品。
