PS2的全基因组序列分析，PS2是一种感染粘质沙雷氏菌临床分离株的新型T4样噬菌体。
Complete genome sequence analysis of PS2, a novel T4-like bacteriophage that infects Serratia marcescens clinical isolates.
作者信息
Teng Tieshan, Zhang Gai, Fan Xiangyu, Zhang Zhenjiang, Zhang Lei, Wu Dongdong, Chen Songjian, Li Yanzhang, Jin Jing
机构信息
Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Department of Pathogen Biology and Immunology, Henan Medical College, Zhengzhou, 451191, China.
出版信息
Arch Virol. 2018 Jul;163(7):1997-2000. doi: 10.1007/s00705-018-3803-0. Epub 2018 Mar 24.
In this study, we isolated and characterized a lytic phage, named vB_SmaM_PS2 (abbreviated as PS2), which can infect Serratia marcescens clinical isolates. Morphologically, phage PS2 can be classified within the Myoviridae family. The 167,276 bp double-stranded DNA genome of PS2 possesses 41.7% GC content. A total of 276 protein-coding genes and 4 tRNA genes were predicted in the PS2 genome. Of the 276 genes, 131 (47%) encoded T4-like genes, most of which are DNA replication and virion structural genes. Therefore, phage PS2 should be a new member of the T4-like Serratia phage.
在本研究中，我们分离并鉴定了一种裂解性噬菌体，命名为vB_SmaM_PS2（简称为PS2），它能够感染粘质沙雷氏菌临床分离株。从形态学上看，噬菌体PS2可归类于肌尾噬菌体科。PS2的167,276 bp双链DNA基因组的GC含量为41.7%。在PS2基因组中总共预测到276个蛋白质编码基因和4个tRNA基因。在这276个基因中，131个（47%）编码类T4基因，其中大多数是DNA复制和病毒粒子结构基因。因此，噬菌体PS2应该是类T4粘质沙雷氏菌噬菌体的一个新成员。
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