1 University of Miami, FL, USA.
2 The University of North Carolina at Chapel Hill, USA.
J Aging Health. 2019 Aug;31(7):1155-1171. doi: 10.1177/0898264318759379. Epub 2018 Mar 24.
To examine the association between diabetes and cognitive function within U.S. Hispanics/Latinos of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American background. This cross-sectional study included 9,609 men and women (mean age = 56.5 years), who are members of the Hispanic Community Health Study/Study of Latinos. We classified participants as having diabetes, prediabetes, or normal glucose regulation. Participants underwent a neurocognitive battery consisting of tests of verbal fluency, delayed recall, and processing speed. Analyses were stratified by Hispanic/Latino subgroup. From fully adjusted linear regression models, compared with having normal glucose regulation, having diabetes was associated with worse processing speed among Cubans (β = -1.99; 95% CI [confidence interval] = [-3.80, -0.19]) and Mexicans (β = -2.26; 95% CI = [-4.02, -0.51]). Compared with having normal glucose regulation, having prediabetes or diabetes was associated with worse delayed recall only among Mexicans (prediabetes: β = -0.34; 95% CI = [-0.63, -0.05] and diabetes: β = -0.41; 95% CI = [-0.79, -0.04]). No associations with verbal fluency. The relationship between diabetes and cognitive function varied across Hispanic/Latino subgroup.
为了研究美国中美洲裔（包括来自萨尔瓦多、危地马拉、洪都拉斯、墨西哥、古巴、多米尼加、波多黎各和南美洲等地的美籍拉丁裔）人群中糖尿病与认知功能之间的关系。本横断面研究纳入了 9609 名男性和女性（平均年龄=56.5 岁），他们均为拉丁裔健康研究/拉丁裔研究的成员。我们将参与者分为糖尿病患者、糖尿病前期患者和血糖正常者。参与者接受了神经认知测试，包括词语流畅性、延迟回忆和处理速度测试。分析按照拉丁裔/西班牙裔亚组进行分层。在经过完全调整的线性回归模型中，与血糖正常者相比，糖尿病与古巴裔（β=-1.99；95%可信区间[CI]：[-3.80，-0.19]）和墨西哥裔（β=-2.26；95%CI：[-4.02，-0.51]）参与者的处理速度更差相关。与血糖正常者相比，仅在墨西哥裔参与者中，糖尿病前期或糖尿病与延迟回忆更差相关（糖尿病前期：β=-0.34；95%CI：[-0.63，-0.05]；糖尿病：β=-0.41；95%CI：[-0.79，-0.04]）。与词语流畅性无关联。糖尿病与认知功能之间的关系在不同的拉丁裔/西班牙裔亚组之间存在差异。
