Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain; Ciber Enfermedades Respiratorias (Ciberes), Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IISGM). Madrid, Spain.
Fisicoquimica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; Instituto de Bioquímica y Medicina Molecular (IBIMOL), Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Department of Nutrition, University of California, Davis, CA, 95616, USA.
Arch Biochem Biophys. 2018 May 15;646:107-112. doi: 10.1016/j.abb.2018.03.022. Epub 2018 Mar 23.
Herein we describe, based on some bibliometric data, how the field of research on flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen in an exponential manner over these years, much faster than other fields on food constituents. This increase appears to be related to the contemporary explosion of interest in healthy foods, supplements and nutraceuticals. It was also probably triggered by large epidemiological studies on fruits and vegetables, and particularly on flavonoids, consumption and incidence of cancer, stroke and coronary heart disease. The widely distributed flavonols constitute the flavonoid subgroup upon which the greatest interest has been focused, followed by flavanols and more recently by anthocyanidins and other related polyphenols such as resveratrol. Research on isoflavones rapidly emerged in the 1990s but plateaued in the 2000s. In the 1990s flavonoids were mainly considered as the active components of medicinal plants, while from 2000 onward, they switched to be mainly regarded as bioactive food ingredients. We envision a continuation in the growth of research for the coming decade focused on clearly demonstrating the importance of flavonoids for human health.
在此，我们根据一些文献计量学数据，描述了过去 25 年来关于类黄酮的研究领域是如何发展的。这些年来，关于类黄酮的论文数量呈指数级增长，其增长速度远远快于其他食品成分领域。这种增长似乎与人们对健康食品、补品和营养保健品的兴趣在当代的爆发有关。它可能也与针对水果和蔬菜的大型流行病学研究有关，特别是与类黄酮、癌症、中风和冠心病的消费和发病率有关。广泛分布的类黄酮构成了最受关注的类黄酮亚群，其次是黄烷醇，最近则是花青素和其他相关多酚，如白藜芦醇。异黄酮的研究在 20 世纪 90 年代迅速出现，但在 21 世纪 00 年代趋于平稳。在 20 世纪 90 年代，类黄酮主要被认为是药用植物的活性成分，而从 2000 年开始，它们主要被认为是具有生物活性的食品成分。我们预计，在未来十年，研究将继续增长，重点是明确证明类黄酮对人类健康的重要性。
