Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel.
Int J Environ Res Public Health. 2018 Mar 27;15(4):606. doi: 10.3390/ijerph15040606.
Enamel demineralization is a common problem found in patients using orthodontic devices, such as orthodontic braces. It was found that growth increases adjacent to orthodontic devices, which may result in caries development. Incorporated antibacterial quaternary ammonium polyethylenimine (QPEI) nanoparticles were previously shown to be highly efficacious against various bacteria. Combining antibacterial materials in orthodontic cement may be advantageous to prevent bacterial outgrowth adjacent to orthodontic brackets. The aim was to evaluate the efficiency of orthodontic cement containing QPEI nanoparticles in reducing and outgrowth adjacent to orthodontic brackets. Orthodontic brackets were bonded to the buccal surfaces of extracted lower incisors. The antibacterial effect on and outgrowth of Neobond bracket adhesive orthodontic cement with and without QPEI nanoparticles was compared. The antibacterial effect was evaluated using crystal violet staining and bacterial count (CFU/mL). The teeth in the experimental group, with the QPEI nanoparticles cement, showed significantly lower optical density (OD) values and CFU counts of and than the teeth in the control group ( < 0.05). Based on the results, it can be concluded that orthodontic cement containing QPEI nanoparticles significantly inhibits and growth around orthodontic brackets.
釉质脱矿是使用正畸装置（如正畸牙套）的患者中常见的问题。研究发现，正畸装置周围的生长增加，这可能导致龋齿的发展。先前已经证明，掺入抗菌季铵盐聚乙烯亚胺（QPEI）纳米颗粒对各种细菌具有高度的功效。在正畸水泥中结合抗菌材料可能有利于防止正畸托槽周围的细菌过度生长。目的是评估含有 QPEI 纳米颗粒的正畸水泥在减少正畸托槽周围 和 的生长方面的效率。将正畸托槽粘结在下切牙的颊面。比较了含有和不含有 QPEI 纳米颗粒的 Neobond 托槽胶正畸水泥对 和 的抗菌效果。使用结晶紫染色和细菌计数（CFU/mL）评估抗菌效果。实验组（含 QPEI 纳米颗粒的水泥）的牙齿的光学密度（OD）值和 和 的 CFU 计数明显低于对照组（ < 0.05）。基于这些结果，可以得出结论，含有 QPEI 纳米颗粒的正畸水泥显著抑制正畸托槽周围 和 的生长。
