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提高负载银化合物的牙科粘结材料的抗菌性能。

Improving the Antibacterial Properties of Dental Bonding Materials Loaded with Silver Compounds.

作者信息

Ferrando-Magraner Elena, García-Sanz Verónica, Bellot-Arcís Carlos, Marín-Gozalbo Anna, Cabedo-Mas Luís, Mínguez-Vega Gladys, Paredes-Gallardo Vanessa

机构信息

Orthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.

Polymers and Advanced Materials Group (PIMA), Universitat Jaume I (UJI), Av. De Vicent Sos Baynat s/n, 12071 Castellón, Spain.

出版信息

Antibiotics (Basel). 2023 Dec 13;12(12):1721. doi: 10.3390/antibiotics12121721.

Abstract

Biofilm accumulation, the appearance of white spot lesions and the development of secondary caries are the main complications in orthodontic patients. A promising approach to fight this situation is the development of adhesive cements with improved antibacterial properties. The aim of the present study was to evaluate the possibility of improving the antibacterial properties of glass ionomer cements by incorporating different types of antimicrobial compounds without altering their physical and mechanical properties. Different concentrations of silver carbonate (SC) and an inorganic glass with encapsulated silver were added to the glass ionomer cement, as well as chitosan, to achieve synergistic antibacterial activity. Variations in the antibacterial capacity were evaluated using the agar diffusion test; the potential alteration of the physical and mechanical properties of the material was analyzed by the shear bond strength test. SEM characterization and colorimetric evaluation were also conducted. Samples of SC up to 1% and inorganic glass with encapsulated silver up to 5% showed significant improvement in their antibacterial ability without compromising shear strength. The highest antimicrobial activity was observed for , with inhibition zones of 3.8 and 3.1 mm for SC and inorganic glass, respectively. The characterization of the samples did not detect any major structural changes between the different samples. The only group that underwent a noticeable color change was the group with SC. The results show that the incorporation of silver carbonate and inorganic glass with encapsulated silver provided the glass ionomer cement with an antibacterial capacity without compromising the bond strength and without modifying the structure of the material.

摘要

生物膜堆积、白斑病变的出现以及继发龋的发展是正畸患者的主要并发症。应对这种情况的一种有前景的方法是开发具有改进抗菌性能的粘结水门汀。本研究的目的是评估在不改变玻璃离子水门汀物理和力学性能的情况下,通过加入不同类型的抗菌化合物来提高其抗菌性能的可能性。向玻璃离子水门汀中添加不同浓度的碳酸银(SC)和包封银的无机玻璃以及壳聚糖,以实现协同抗菌活性。使用琼脂扩散试验评估抗菌能力的变化;通过剪切粘结强度试验分析材料物理和力学性能的潜在改变。还进行了扫描电子显微镜(SEM)表征和比色评估。高达1%的SC样品和高达5%的包封银无机玻璃样品在不影响剪切强度的情况下,抗菌能力有显著提高。对于SC和无机玻璃,观察到最高抗菌活性,其抑菌圈分别为3.8和3.1毫米。样品表征未检测到不同样品之间有任何重大结构变化。唯一出现明显颜色变化的组是含有SC的组。结果表明,加入碳酸银和包封银的无机玻璃赋予了玻璃离子水门汀抗菌能力,同时不影响粘结强度且不改变材料结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7985/10741129/2c53cf4b352c/antibiotics-12-01721-g001.jpg

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