Golzari Mohammad Hassan, Javanbakht Mohammad Hassan, Ghaedi Ehsan, Mohammadi Hamed, Djalali Mahmoud
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Diabetes Metab Syndr. 2018 May;12(3):411-415. doi: 10.1016/j.dsx.2018.03.003. Epub 2018 Mar 16.
Cardiovascular complications are one of main cause of increased mortality and morbidity among Diabetes Mellitus (DM) patients. Altered metabolism of sulphur amino acids in diabetes reflected as increases in concentration of methionine and cysteine/cystine in the blood which known as a markers of Cardiovascular Diseases (CVD). The aim of present study was to determine the effect of Eicosapentaenoic acid (EPA) supplementation on sulfhydryl amino acids and Atherogenic Index of Plasma (AIP) in patients with type 2 DM (T2DM).
A randomized, double-blind, placebo-controlled clinical trial was performed in 36 control and patients with DM. The subjects were randomly assigned to obtain 2 g/d EPA (n = 18) or placebo (n = 18) for 8 weeks. Fasting serum level of Cystein and Methionine were measured using HPLC method and atherogenic index of plasma (AIP) as a proxy measure of atherosclerosis was computed.
Eight weeks supplementation with EPA led to significant reductions in Met (p < 0.002) and Cys (p < 0.001) compared with the placebo (p < 0.06). In addition, compared to placebo a significant reduction in AIP were seen after taking EPA (p < 0.04).
EPA supplementation in patients with T2DM for eight weeks had beneficial effects on Met, Cys and AIP, which may attribute to the prevention of vascular complications in the T2DM patients.
心血管并发症是糖尿病（DM）患者死亡率和发病率增加的主要原因之一。糖尿病患者硫氨基酸代谢改变表现为血液中甲硫氨酸和半胱氨酸/胱氨酸浓度升高，这被认为是心血管疾病（CVD）的标志物。本研究的目的是确定补充二十碳五烯酸（EPA）对2型糖尿病（T2DM）患者巯基氨基酸和血浆致动脉粥样硬化指数（AIP）的影响。
对36名对照者和糖尿病患者进行了一项随机、双盲、安慰剂对照的临床试验。受试者被随机分配，连续8周每天摄入2克EPA（n = 18）或安慰剂（n = 18）。使用高效液相色谱法测量空腹血清半胱氨酸和甲硫氨酸水平，并计算血浆致动脉粥样硬化指数（AIP）作为动脉粥样硬化的替代指标。
与安慰剂组相比（p < 0.06），补充EPA 8周后，甲硫氨酸（p < 0.002）和半胱氨酸（p < 0.001）显著降低。此外，与安慰剂组相比，服用EPA后AIP显著降低（p < 0.04）。
T2DM患者补充EPA 8周对甲硫氨酸、半胱氨酸和AIP有有益影响，这可能归因于预防T2DM患者的血管并发症。
