Smith Caroline A, Levett Kate M, Collins Carmel T, Dahlen Hannah G, Ee Carolyn C, Suganuma Machiko
National Institute of Complementary Medicine (NICM), Western Sydney University, Locked Bag 1797, Penrith, New South Wales, Australia, 2751.
Cochrane Database Syst Rev. 2018 Mar 28;3(3):CD009290. doi: 10.1002/14651858.CD009290.pub3.
Many women would like to avoid pharmacological or invasive methods of pain management in labour, and this may contribute towards the popularity of complementary methods of pain management. This review examined the evidence currently available on manual methods, including massage and reflexology, for pain management in labour. This review is an update of the review first published in 2012.
To assess the effect, safety and acceptability of massage, reflexology and other manual methods to manage pain in labour.
For this update, we searched Cochrane Pregnancy and Childbirth's Trials Register (30 June 2017), the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 6), MEDLINE (1966 to 30 June 2017, CINAHL (1980 to 30 June 2017), the Australian New Zealand Clinical Trials Registry (4 August 2017), Chinese Clinical Trial Registry (4 August 2017), ClinicalTrials.gov, (4 August 2017), the National Center for Complementary and Integrative Health (4 August 2017), the WHO International Clinical Trials Registry Platform (ICTRP) (4 August 2017) and reference lists of retrieved trials.
We included randomised controlled trials comparing manual methods with standard care, other non-pharmacological forms of pain management in labour, no treatment or placebo. We searched for trials of the following modalities: massage, warm packs, thermal manual methods, reflexology, chiropractic, osteopathy, musculo-skeletal manipulation, deep tissue massage, neuro-muscular therapy, shiatsu, tuina, trigger point therapy, myotherapy and zero balancing. We excluded trials for pain management relating to hypnosis, aromatherapy, acupuncture and acupressure; these are included in other Cochrane reviews.
Two review authors independently assessed trial quality, extracted data and checked data for accuracy. We contacted trial authors for additional information. We assessed the quality of the evidence using the GRADE approach.
We included a total of 14 trials; 10 of these (1055 women) contributed data to meta-analysis. Four trials, involving 274 women, met our inclusion criteria but did not contribute data to the review. Over half the trials had a low risk of bias for random sequence generation and attrition bias. The majority of trials had a high risk of performance bias and detection bias, and an unclear risk of reporting bias. We found no trials examining the effectiveness of reflexology.MassageWe found low-quality evidence that massage provided a greater reduction in pain intensity (measured using self-reported pain scales) than usual care during the first stage of labour (standardised mean difference (SMD) -0.81, 95% confidence interval (CI) -1.06 to -0.56, six trials, 362 women). Two trials reported on pain intensity during the second and third stages of labour, and there was evidence of a reduction in pain scores in favour of massage (SMD -0.98, 95% CI -2.23 to 0.26, 124 women; and SMD -1.03, 95% CI -2.17 to 0.11, 122 women). There was very low-quality evidence showing no clear benefit of massage over usual care for the length of labour (in minutes) (mean difference (MD) 20.64, 95% CI -58.24 to 99.52, six trials, 514 women), and pharmacological pain relief (average risk ratio (RR) 0.81, 95% CI 0.37 to 1.74, four trials, 105 women). There was very low-quality evidence showing no clear benefit of massage for assisted vaginal birth (average RR 0.71, 95% CI 0.44 to 1.13, four trials, 368 women) and caesarean section (RR 0.75, 95% CI 0.51 to 1.09, six trials, 514 women). One trial reported less anxiety during the first stage of labour for women receiving massage (MD -16.27, 95% CI -27.03 to -5.51, 60 women). One trial found an increased sense of control from massage (MD 14.05, 95% CI 3.77 to 24.33, 124 women, low-quality evidence). Two trials examining satisfaction with the childbirth experience reported data on different scales; both found more satisfaction with massage, although the evidence was low quality in one study and very low in the other.Warm packsWe found very low-quality evidence for reduced pain (Visual Analogue Scale/VAS) in the first stage of labour (SMD -0.59, 95% CI -1.18 to -0.00, three trials, 191 women), and the second stage of labour (SMD -1.49, 95% CI -2.85 to -0.13, two trials, 128 women). Very low-quality evidence showed reduced length of labour (minutes) in the warm-pack group (MD -66.15, 95% CI -91.83 to -40.47; two trials; 128 women).Thermal manual methodsOne trial evaluated thermal manual methods versus usual care and found very low-quality evidence of reduced pain intensity during the first phase of labour for women receiving thermal methods (MD -1.44, 95% CI -2.24 to -0.65, one trial, 96 women). There was a reduction in the length of labour (minutes) (MD -78.24, 95% CI -118.75 to -37.73, one trial, 96 women, very low-quality evidence). There was no clear difference for assisted vaginal birth (very low-quality evidence). Results were similar for cold packs versus usual care, and intermittent hot and cold packs versus usual care, for pain intensity, length of labour and assisted vaginal birth.Music One trial that compared manual methods with music found very low-quality evidence of reduced pain intensity during labour in the massage group (RR 0.40, 95% CI 0.18 to 0.89, 101 women). There was no evidence of benefit for reduced use of pharmacological pain relief (RR 0.41, 95% CI 0.16 to 1.08, very low-quality evidence).Of the seven outcomes we assessed using GRADE, only pain intensity was reported in all comparisons. Satisfaction with the childbirth experience, sense of control, and caesarean section were rarely reported in any of the comparisons.
AUTHORS' CONCLUSIONS: Massage, warm pack and thermal manual methods may have a role in reducing pain, reducing length of labour and improving women's sense of control and emotional experience of labour, although the quality of evidence varies from low to very low and few trials reported on the key GRADE outcomes. Few trials reported on safety as an outcome. There is a need for further research to address these outcomes and to examine the effectiveness and efficacy of these manual methods for pain management.
许多女性希望避免在分娩时采用药物或侵入性疼痛管理方法,这可能促使辅助性疼痛管理方法更受欢迎。本综述考察了目前关于包括按摩和反射疗法在内的手动方法用于分娩疼痛管理的证据。本综述是2012年首次发表的综述的更新版。
评估按摩、反射疗法及其他手动方法用于分娩疼痛管理的效果、安全性及可接受性。
本次更新,我们检索了Cochrane妊娠与分娩试验注册库(2017年6月30日)、Cochrane对照试验中央注册库(CENTRAL;2017年第6期)、MEDLINE(1966年至2017年6月30日)、CINAHL(1980年至2017年6月30日)、澳大利亚新西兰临床试验注册库(2017年8月4日)、中国临床试验注册库(2017年8月4日)、ClinicalTrials.gov(2017年8月4日)、美国国立补充与综合健康中心(2017年8月4日)、世界卫生组织国际临床试验注册平台(ICTRP)(2017年8月4日)以及检索到的试验的参考文献列表。
我们纳入了将手动方法与标准护理、分娩时其他非药物性疼痛管理形式、不治疗或安慰剂进行比较的随机对照试验。我们检索了以下方式的试验:按摩、热敷包、温热手动方法、反射疗法、整脊疗法、骨疗法、肌肉骨骼手法治疗、深层组织按摩、神经肌肉疗法、指压疗法、推拿、触发点疗法、肌疗法和零平衡疗法。我们排除了与催眠、芳香疗法、针灸和穴位按压相关的疼痛管理试验;这些内容包含在其他Cochrane综述中。
两位综述作者独立评估试验质量、提取数据并检查数据准确性。我们联系试验作者获取更多信息。我们采用GRADE方法评估证据质量。
我们共纳入14项试验;其中10项试验(1055名女性)为荟萃分析提供了数据。4项试验,涉及274名女性,符合我们的纳入标准,但未为综述提供数据。超过一半的试验在随机序列生成和失访偏倚方面存在低偏倚风险。大多数试验在实施偏倚和检测偏倚方面存在高偏倚风险,报告偏倚风险不明确。我们未发现考察反射疗法有效性的试验。
我们发现低质量证据表明,在分娩第一产程中,按摩比常规护理能更大程度地减轻疼痛强度(使用自我报告疼痛量表测量)(标准化均数差(SMD)-0.81,95%置信区间(CI)-1.06至-0.56,6项试验,362名女性)。两项试验报告了第二和第三产程中的疼痛强度,有证据表明按摩组疼痛评分降低(SMD -0.98,95% CI -2.23至0.26,124名女性;以及SMD -1.03,95% CI -2.17至0.11,122名女性)。有极低质量证据表明,按摩在分娩时长(分钟)方面相较于常规护理无明显益处(均数差(MD)20.64,95% CI -58.24至99.52,6项试验,514名女性),在药物性疼痛缓解方面也无明显益处(平均风险比(RR)0.81,95% CI 0.37至1.74,4项试验,105名女性)。有极低质量证据表明,按摩在辅助阴道分娩方面无明显益处(平均RR 0.71,95% CI 0.44至1.13,4项试验,368名女性),在剖宫产方面也无明显益处(RR 0.75,95% CI 0.51至1.09,6项试验,514名女性)。一项试验报告称,接受按摩的女性在分娩第一产程中的焦虑程度较低(MD -16.27,95% CI -27.03至-5.51,60名女性)。一项试验发现按摩能增强控制感(MD 14.05,95% CI 3.77至24.33,124名女性,低质量证据)。两项考察对分娩体验满意度的试验报告了不同量表的数据;两项试验均发现对按摩的满意度更高,尽管一项研究中的证据质量较低,另一项研究中的证据质量极低。
我们发现极低质量证据表明,热敷包可减轻分娩第一产程中的疼痛(视觉模拟评分法/VAS)(SMD -0.59,95% CI -1.18至-0.00,3项试验,191名女性),以及第二产程中的疼痛(SMD -1.49,95% CI -2.85至-0.13,2项试验,128名女性)。极低质量证据表明,热敷包组的分娩时长(分钟)缩短(MD -66.15,95% CI -91.83至-40.47;2项试验;128名女性)。
一项试验评估了温热手动方法与常规护理,发现极低质量证据表明,接受温热方法的女性在分娩第一阶段疼痛强度降低(MD -1.44,95% CI -2.24至-0.65,1项试验,96名女性)。分娩时长(分钟)缩短(MD -78.24,95% CI -118.75至-37.73,1项试验,96名女性,极低质量证据)。辅助阴道分娩方面无明显差异(极低质量证据)。冷敷包与常规护理、间歇性冷热敷包与常规护理在疼痛强度、分娩时长和辅助阴道分娩方面的结果相似。
一项将手动方法与音乐进行比较的试验发现,极低质量证据表明按摩组在分娩期间疼痛强度降低(RR 0.40,95% CI 0.18至0.89,101名女性)。在减少药物性疼痛缓解的使用方面无益处证据(RR 0.41,95% CI 0.16至1.08,极低质量证据)。
在我们使用GRADE评估的7项结局中,所有比较中仅报告了疼痛强度。在任何比较中,很少报告对分娩体验的满意度、控制感和剖宫产情况。
按摩、热敷包和温热手动方法可能在减轻疼痛、缩短分娩时长以及改善女性的控制感和分娩情绪体验方面发挥作用,尽管证据质量从低到极低不等,且很少有试验报告关键的GRADE结局。很少有试验将安全性作为结局进行报告。需要进一步研究以解决这些结局问题,并考察这些手动方法用于疼痛管理的有效性和疗效。