Sarıfakıoğlu Banu, Güzelant Aliye Yıldırım, Güzel Eda Celik, Güzel Savaş, Kızıler Ali Rıza
Department of Physical Medicine and Rehabilitation, School of Medicine, Namik Kemal University, 100, Yıl Mah, Barbaros Cad. Merkez, Tekirdağ, Turkey,
Rheumatol Int. 2014 Oct;34(10):1361-7. doi: 10.1007/s00296-014-2978-2. Epub 2014 Mar 9.
The aims of this study were to investigate the effect of exercise therapy on the oxidative stress in fibromyalgia patients and relationship between oxidative stress and fibromyalgia symptoms. Thirty women diagnosed with fibromyalgia according to the American College of Rheumatology preliminary criteria, and 23 healthy women whose age- and weight-matched women were enrolled the study. Pain intensity with visual analog scale (VAS), the number of tender points, the fibromyalgia impact questionnaire (FIQ), the Beck depression inventory (BDI) were evaluated. The oxidative stress parameters thiobarbituric acid reactive substances, protein carbonyls, and nitric oxide, and antioxidant parameters thiols and catalase were investigated in patients and control group. After, combined aerobic and strengthen exercise regimen was given to fibromyalgia group. Exercise therapy consisted of a warming period of 10 min, aerobic exercises period of 20 min, muscle strengthening exercises for 20 min, and 10 min cooling down period. Therapy was lasting 1 h three times per week over a 12-week period. All parameters were reevaluated after the treatment in the patient group. The oxidative stress parameters levels were significantly higher, and antioxidant parameters were significantly lower in patients with fibromyalgia than in the controls. VAS, FIQ, and BDI scores decreased significantly with exercise therapy. The exercise improved all parameters of oxidative stress and antioxidant parameters. Also, all clinical parameters were improved with exercise. We should focus on oxidative stress in the treatment for fibromyalgia with the main objective of reducing oxidative load.
本研究的目的是调查运动疗法对纤维肌痛患者氧化应激的影响以及氧化应激与纤维肌痛症状之间的关系。根据美国风湿病学会初步标准诊断为纤维肌痛的30名女性和23名年龄及体重匹配的健康女性纳入本研究。采用视觉模拟量表（VAS）评估疼痛强度、压痛点数量、纤维肌痛影响问卷（FIQ）、贝克抑郁量表（BDI）。对患者和对照组进行氧化应激参数硫代巴比妥酸反应性物质、蛋白质羰基和一氧化氮以及抗氧化参数硫醇和过氧化氢酶的检测。之后，对纤维肌痛组进行有氧和强化运动相结合的方案。运动疗法包括10分钟的热身期、20分钟的有氧运动期、20分钟的肌肉强化运动以及10分钟的冷却期。治疗为期12周，每周三次，每次1小时。患者组治疗后重新评估所有参数。纤维肌痛患者的氧化应激参数水平显著高于对照组，抗氧化参数则显著低于对照组。运动疗法使VAS、FIQ和BDI评分显著降低。运动改善了氧化应激和抗氧化参数的所有指标。此外，运动使所有临床参数均得到改善。我们应以减轻氧化负荷为主要目标，在纤维肌痛治疗中关注氧化应激。
