Schools of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4004, South Africa.
Molecules. 2018 Mar 29;23(4):794. doi: 10.3390/molecules23040794.
Prolonged exposure to high energy diets has been implicated in the development of pre-diabetes, a long-lasting condition that precedes type 2 diabetes mellitus (T2DM). A combination of pharmacological and dietary interventions is used to prevent the progression of pre-diabetes to T2DM. However, poor patient compliance leads to negligence of the dietary intervention and thus reduced drug efficiency. Oleanolic acid (OA) has been reported to possess anti-diabetic effects in type 1 diabetic rats. However, the effects of this compound on pre-diabetes have not yet been established. Consequently, this study sought to evaluate the effects OA on a diet-induced pre-diabetes rat model. Pre-diabetic male Sprague Dawley rats were treated with OA in both the presence and absence of dietary intervention for a period of 12 weeks. The administration of OA with and without dietary intervention resulted in significantly improved glucose homeostasis through reduced caloric intake, body weights, plasma ghrelin concentration and glycated haemoglobin by comparison to the pre-diabetic control. These results suggest that OA may be used to manage pre-diabetes as it was able to restore glucose homeostasis and prevented the progression to overt type 2 diabetes.
长期摄入高热量饮食与前驱糖尿病的发生有关，前驱糖尿病是一种长期存在的状态，先于 2 型糖尿病（T2DM）发生。药物和饮食干预的联合应用可预防前驱糖尿病向 T2DM 的进展。然而，患者依从性差导致饮食干预被忽视，从而降低了药物的疗效。齐墩果酸（OA）已被报道在 1 型糖尿病大鼠中具有抗糖尿病作用。然而，该化合物对前驱糖尿病的影响尚未确定。因此，本研究旨在评估 OA 对饮食诱导的前驱糖尿病大鼠模型的影响。将前驱糖尿病雄性 Sprague Dawley 大鼠用 OA 治疗，同时存在和不存在饮食干预，持续 12 周。与前驱糖尿病对照组相比，OA 的给药（无论是否有饮食干预）通过减少热量摄入、体重、血浆 ghrelin 浓度和糖化血红蛋白，显著改善了葡萄糖稳态。这些结果表明，OA 可用于治疗前驱糖尿病，因为它能够恢复葡萄糖稳态，并防止进展为明显的 2 型糖尿病。
