Leng Fan, Liu Fang, Yang Yongtao, Wu Yu, Tian Weiqun
Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
Nanomaterials (Basel). 2018 Mar 28;8(4):202. doi: 10.3390/nano8040202.
The emergence of nanomedicine has enriched the knowledge and strategies of treating diseases, and especially some incurable diseases, such as cancers, acquired immune deficiency syndrome (AIDS), and neurodegenerative diseases. The application of nanoparticles in medicine is in the core of nanomedicine. Nanoparticles can be used in drug delivery for improving the uptake of poorly soluble drugs, targeted delivery to a specific site, and drug bioavailability. Early diagnosis of and targeted therapies for cancers can significantly improve patients' quality of life and extend patients' lives. The advantages of nanoparticles have given them a progressively important role in the nanodiagnosis and nanotherapy of common cancers. To provide a reference for the further application of nanoparticles, this review focuses on the recent development and application of nanoparticles in the early diagnosis and treatment of the three common cancers (lung cancer, liver cancer, and breast cancer) by using quantum dots, magnetic nanoparticles, and gold nanoparticles.
纳米医学的出现丰富了疾病治疗的知识和策略，尤其是一些不治之症，如癌症、获得性免疫缺陷综合征（艾滋病）和神经退行性疾病。纳米颗粒在医学中的应用是纳米医学的核心。纳米颗粒可用于药物递送，以提高难溶性药物的摄取、靶向递送至特定部位以及药物生物利用度。癌症的早期诊断和靶向治疗可显著提高患者的生活质量并延长患者寿命。纳米颗粒的优势使其在常见癌症的纳米诊断和纳米治疗中发挥着越来越重要的作用。为纳米颗粒的进一步应用提供参考，本综述重点介绍了量子点、磁性纳米颗粒和金纳米颗粒在三种常见癌症（肺癌、肝癌和乳腺癌）早期诊断和治疗中的最新进展及应用。
