Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan 410011, China.
Mediators Inflamm. 2018 Feb 11;2018:8050956. doi: 10.1155/2018/8050956. eCollection 2018.
The innate immune system is the first line of defense against microbial pathogens. The activated innate immune system plays important roles in eliciting antimicrobial defenses. Despite the benefits of innate immune responses, excessive inflammation will cause host damage. Thus, tight regulation of these processes is required for the maintenance of immune homeostasis. Recently, a new class of long noncoding RNAs (lncRNAs) has emerged as important regulators in many physiological and pathological processes. Dysregulated lncRNAs have been found to be associated with excessive or uncontrolled inflammation. In this brief review, we summarize the roles of functional lncRNAs in regulating innate immune responses. We also discuss the roles of lncRNAs in macrophage polarization, an important molecular event in the innate immune responses.
先天免疫系统是抵御微生物病原体的第一道防线。激活的先天免疫系统在引发抗菌防御方面发挥着重要作用。尽管先天免疫反应有其益处，但过度的炎症会导致宿主损伤。因此，需要对这些过程进行严格的调节，以维持免疫平衡。最近，一类新的长非编码 RNA（lncRNA）作为许多生理和病理过程中的重要调节剂而出现。失调的 lncRNA 已被发现与过度或失控的炎症有关。在这篇简要综述中，我们总结了功能性 lncRNA 在调节先天免疫反应中的作用。我们还讨论了 lncRNA 在巨噬细胞极化中的作用，这是先天免疫反应中的一个重要分子事件。
