Institute for Lung Research, Philipps University Marburg, Marburg, Germany.
German Center for Lung Research (DZL), Philipps University Marburg, Marburg, Germany.
RNA Biol. 2021 May;18(5):587-603. doi: 10.1080/15476286.2020.1845505. Epub 2020 Nov 19.
The innate immune system relies on a germ-line-encoded repertoire of pattern recognition receptors (PRRs), activated by deeply conserved pathogen signatures, such as bacterial cell wall components or foreign nucleic acids. To enable effective defence against invading pathogens and prevent from deleterious inflammation, PRR-driven immune responses are tightly controlled by a dense network of nuclear and cytoplasmic regulators. Long non-coding RNAs (lncRNAs) are increasingly recognized as important components of these regulatory circuitries, providing positive and negative control of PRR-induced innate immune responses. The present review provides an overview of the presently known roles of lncRNAs in human and murine innate antiviral and antibacterial immunity. The emerging roles in host defence and inflammation suggest that further mechanistic insights into the cellular functions of lncRNAs will decisively advance our molecular understanding of immune-associated diseases and open new avenues for therapeutic intervention.
固有免疫系统依赖于一套由胚系编码的模式识别受体（PRRs），这些受体可被高度保守的病原体特征激活，例如细菌细胞壁成分或外源核酸。为了有效抵御入侵的病原体并防止有害的炎症，PRR 驱动的免疫反应受到核和细胞质调节剂的密集网络的严格控制。长非编码 RNA（lncRNA）越来越被认为是这些调节回路的重要组成部分，对 PRR 诱导的固有免疫反应提供正调控和负调控。本综述概述了目前已知的 lncRNA 在人类和鼠类固有抗病毒和抗细菌免疫中的作用。在宿主防御和炎症中的新兴作用表明，对 lncRNA 细胞功能的进一步机制研究将极大地促进我们对免疫相关疾病的分子理解，并为治疗干预开辟新途径。
