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氟化物与纳米羟基磷灰石对早期釉质龋再矿化作用的体外比较研究

Comparison between Fluoride and Nano-hydroxyapatite in Remineralizing Initial Enamel Lesion: An in vitro Study.

作者信息

Daas Issa, Badr Sherine, Osman Essam

机构信息

Division of Pediatric Dentistry, Department of Developmental Sciences, Faculty of Dentistry, Beirut Arab University, Beirut Lebanon, Phone: +962791959718, e-mail:

Division of Pediatric Dentistry, Department of Developmental Sciences, Faculty of Dentistry, Beirut Arab University, Beirut Lebanon; Department of Pediatric Dentistry and Public Health Cairo University, Giza, Egypt.

出版信息

J Contemp Dent Pract. 2018 Mar 1;19(3):306-312.

Abstract

AIM

The aim of this study was to compare the effectiveness of nano-hydroxyapatite (nano-HAP) paste and fluoride varnish in remineralizing initial enamel lesion in young permanent teeth and their ability to resist secondary caries under dynamic pH cycling quantitatively and qualitatively.

MATERIALS AND METHODS

Initial caries-like lesions were artificially developed on 45 specimens. Specimens were divided into three groups: (1) Control (without treatment), (2) fluoride varnish (3M ESPE), and (3) nano-HAP paste (Desensibilize Nano P). The nano-HAP paste was applied twice separated by one pH cycle, and the varnish was applied only once followed by 7 days of pH cycling. All specimens were examined using DIAGNOdent® pen (KaVo, Germany), and a representative specimen was randomly selected from each group for qualitative evaluation using scanning electron microscope (SEM) at four stages: Baseline, after lesion formation, immediately after remineralization, and after pH cycling. Data were statistically analyzed with Statistical Package for the Social Sciences (SPSS), version 20.

RESULTS

The degree of demineralization was significantly elevated in control group; however, no significant difference was found between fluoride varnish group and nano-HAP paste group (p < 0.001).

CONCLUSION

Nano-HAP paste showed promising long-term protective effect in terms of surface depositions and maintaining a smooth surface compared with fluoride varnish.

CLINICAL SIGNIFICANCE

Based on the findings of this study, nano-HAP paste might be recommended as alternative remineralizing agent with lower fluoride concentration than fluoride varnish that could be beneficial for children, pregnant females, and those who are at high risk of dental fluorosis.

摘要

目的

本研究旨在定量和定性比较纳米羟基磷灰石(nano-HAP)糊剂和含氟涂料对年轻恒牙初期釉质病变再矿化的效果及其在动态pH循环下抵抗继发龋的能力。

材料与方法

在45个标本上人工形成类似初期龋的病变。标本分为三组:(1)对照组(未治疗),(2)含氟涂料(3M ESPE),(3)纳米羟基磷灰石糊剂(Desensibilize Nano P)。纳米羟基磷灰石糊剂分两次涂抹,间隔一个pH循环,含氟涂料仅涂抹一次,随后进行7天的pH循环。所有标本均使用DIAGNOdent®笔(德国卡瓦)进行检查,并从每组中随机选取一个代表性标本,在四个阶段使用扫描电子显微镜(SEM)进行定性评估:基线期、病变形成后、再矿化后即刻以及pH循环后。数据采用社会科学统计软件包(SPSS)20版进行统计学分析。

结果

对照组的脱矿程度显著升高;然而,含氟涂料组和纳米羟基磷灰石糊剂组之间未发现显著差异(p < 0.001)。

结论

与含氟涂料相比,纳米羟基磷灰石糊剂在表面沉积和保持表面光滑方面显示出有前景的长期保护作用。

临床意义

基于本研究结果,纳米羟基磷灰石糊剂可能被推荐作为一种再矿化剂,其氟浓度低于含氟涂料,这对儿童、孕妇以及那些患氟斑牙风险较高的人可能有益。

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