Laboratório de Virologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Rio Branco, AC, Brazil.
Transbound Emerg Dis. 2018 Oct;65(5):1381-1395. doi: 10.1111/tbed.12868. Epub 2018 Mar 30.
Papillomaviruses (PVs) are complex viruses which infect the skin or mucosae of a broad range of amniotes worldwide. They cause benign or malignant lesions depending on environmental factors, virus oncogenicity and the location of infection. Bovine papillomaviruses (BPVs) are the second most studied PVs beyond human PVs. In the past few years, genetic characterization of animal PVs has increased due to the availability of new techniques, which simplified the sequencing of entire genomes. Therefore, this review aims to provide an update of the current epidemiology, classification and genome features of ruminant PVs (mainly BPVs) affecting animals worldwide. The review also aimed to clarify the key differences between the high-risk Delta papillomaviruses and the seemingly low-risk Xi, Epsilon, Dyoxi and Dyokappapillomavirus as well as the recently described PVs BPV18, 19, 21 and PpuPV1 that belongs to an unclassified genus.
乳头瘤病毒（PVs）是一类复杂的病毒，可感染全球范围内的广泛有胎盘动物的皮肤或黏膜。它们根据环境因素、病毒致癌性和感染部位的不同，引起良性或恶性病变。牛乳头瘤病毒（BPVs）是仅次于人类乳头瘤病毒（HPV）的第二大研究最多的 PV 之一。在过去的几年中，由于新技术的出现，简化了整个基因组的测序，动物乳头瘤病毒（PVs）的遗传特征分析得到了增加。因此，本综述旨在提供目前全球范围内影响动物的反刍动物乳头瘤病毒（主要是 BPVs）的流行病学、分类和基因组特征的最新信息。本综述还旨在阐明高危型 Delta 乳头瘤病毒与看似低危型 Xi、Epsilon、Dyoxi 和 Dyokappapillomavirus 以及最近描述的 BPV18、19、21 和 PpuPV1 之间的关键区别，后者属于未分类属。
