Safety and ADME Translational Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Oncology Translational Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Clin Pharmacol Ther. 2018 Oct;104(4):644-654. doi: 10.1002/cpt.1080. Epub 2018 May 1.
Balancing antitumor efficacy with toxicity is a significant challenge, and drug-induced myelosuppression is a common dose-limiting toxicity of cancer treatments. Mathematical modeling has proven to be a powerful ally in this field, scaling results from animal models to humans, and designing optimized treatment regimens. Here we outline existing mathematical approaches for studying bone marrow toxicity, identify gaps in current understanding, and make future recommendations to advance this vital field of safety research further.
在抗肿瘤疗效与毒性之间取得平衡是一项重大挑战，而药物引起的骨髓抑制是癌症治疗中常见的剂量限制性毒性。数学建模已被证明是该领域的有力工具，可将动物模型的结果扩展到人类，并设计优化的治疗方案。在这里，我们概述了现有的用于研究骨髓毒性的数学方法，确定了当前理解中的差距，并提出了未来的建议，以进一步推进这一重要的安全研究领域。
