应对必需毒物：遗传抑制剂分析证实 c-di-AMP 在革兰氏阳性菌控制钾离子稳态中的关键作用。
Coping with an Essential Poison: a Genetic Suppressor Analysis Corroborates a Key Function of c-di-AMP in Controlling Potassium Ion Homeostasis in Gram-Positive Bacteria.
机构信息
Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August University Göttingen, Germany.
Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August University Göttingen, Germany
出版信息
J Bacteriol. 2018 May 24;200(12). doi: 10.1128/JB.00166-18. Print 2018 Jun 15.
Abstract
Cyclic di-AMP (c-di-AMP) is an important second messenger in bacteria. In most , the molecule is required for growth in complex media but also toxic upon accumulation. In an article on their current study, Zarrella and coworkers present a suppressor analysis of a strain that is unable to degrade c-di-AMP (T. M. Zarrella, D. W. Metzger, and G. Bai, J Bacteriol 200:e00045-18, 2018, https://doi.org/10.1128/JB.00045-18). Their study identifies new links between c-di-AMP and potassium homeostasis and supports the hypothesis that c-di-AMP serves as a second messenger to report about the intracellular potassium concentrations.
摘要
环二鸟苷酸（c-di-AMP）是细菌中一种重要的第二信使。在大多数情况下，该分子是在复杂培养基中生长所必需的，但积累过多时也会有毒性。在一篇关于他们当前研究的文章中，Zarrella 和同事们对一种不能降解 c-di-AMP 的 进行了抑制分析（T. M. Zarrella、D. W. Metzger 和 G. Bai，J Bacteriol 200:e00045-18，2018，https://doi.org/10.1128/JB.00045-18）。他们的研究发现了 c-di-AMP 与钾离子稳态之间的新联系，并支持了 c-di-AMP 作为一种第二信使来报告细胞内钾离子浓度的假说。
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