Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155645, Iran.
Curr Med Chem. 2019;26(13):2389-2406. doi: 10.2174/0929867325666180403145137.
Cancer continues to be a global burden, despite the advancement of various technological and pharmaceutical improvements over the past two decades. Methods for treating cancer include surgery, radiotherapy and chemotherapy in addition to other specialized techniques. On the other hand, medicinal plants have been traditionally employed either as the complementary medicine or dietary agents in the treatment and management of cancer. Medicinal plants are a rich source of secondary metabolites with interesting biological and pharmacological activities. Among these metabolites, glycosides are naturally occurring substances and have outstanding therapeutic potential and clinical utility.
Different medical research engines such as, GoogleScholar, PubMed, SpringerLink, ScienceDirect were used to collect related literature on the subject matter. In this regard, only peer-reviewed journals were considered.
Emerging results showed that numerous glycosides isolated from various plants possessed marked anticancer activity against a variety of cancer cell lines. Accordingly, the aim of the present review is to shed light on the anticancer effects of glycosides, analyze possible mechanisms of action, and highlight the role of these natural agents as complementary and alternative medicine in combating and managing cancer.
The glycosides isolated from different plants demonstrated potent cytotoxic effects against various cancer cell lines in initial preclinical studies. The anticancer effect was mediated through multiple mechanisms; however further detailed studies are needed to understand the full potential of glycosides for clinical utility.
尽管在过去的二十年中，各种技术和药物方面取得了进步，但癌症仍然是全球的负担。癌症的治疗方法除了其他专门技术外，还包括手术、放疗和化疗。另一方面，药用植物在传统上被用作癌症治疗和管理的补充药物或膳食补充剂。药用植物是具有有趣的生物和药理活性的次生代谢产物的丰富来源。在这些代谢产物中，糖苷是天然存在的物质，具有出色的治疗潜力和临床实用性。
使用不同的医学研究引擎，如 Google Scholar、PubMed、SpringerLink、ScienceDirect 等，收集有关该主题的相关文献。在这方面，只考虑了经过同行评审的期刊。
新出现的结果表明，从各种植物中分离出的许多糖苷对多种癌细胞系具有显著的抗癌活性。因此，本综述的目的是阐明糖苷的抗癌作用，分析可能的作用机制，并强调这些天然药物作为对抗和管理癌症的补充和替代医学的作用。
不同植物中分离出的糖苷在初步临床前研究中对各种癌细胞系表现出强烈的细胞毒性作用。抗癌作用是通过多种机制介导的；然而，需要进一步的详细研究来了解糖苷在临床应用中的全部潜力。
