内外型 Diels-Alder 加合物：用于选择性化学功能化的温度可调构建块。
Endo and Exo Diels-Alder Adducts: Temperature-Tunable Building Blocks for Selective Chemical Functionalization.
机构信息
Department of Chemistry , Ajou University , Suwon 16499 , Korea.
出版信息
J Am Chem Soc. 2018 Apr 18;140(15):5009-5013. doi: 10.1021/jacs.8b01544. Epub 2018 Apr 3.
Abstract
The development and application of a novel endo furan-protected maleimide building block is reported. The endo isomer undergoes deprotection at temperatures ∼50 °C below the exo derivative. This enables a simple and powerful approach to quantitatively and selectively introduce functional maleimide groups via temperature modulation.
摘要
报告了一种新型内型呋喃保护马来酰亚胺砌块的开发和应用。内型异构体在比外型衍生物低约 50°C 的温度下进行去保护。这使得通过温度调节定量且选择性地引入功能马来酰亚胺基团成为一种简单而强大的方法。
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