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用于增强人骨髓干细胞成骨分化的微/纳米结构钽涂层

Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells.

作者信息

Ding Ding, Xie Youtao, Li Kai, Huang Liping, Zheng Xuebin

机构信息

Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China.

University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.

出版信息

Materials (Basel). 2018 Apr 3;11(4):546. doi: 10.3390/ma11040546.

DOI:10.3390/ma11040546
PMID:29614022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5951430/
Abstract

Recently, tantalum has been attracting much attention for its anticorrosion resistance and biocompatibility, and it has been widely used in surface modification for implant applications. To improve its osteogenic differentiation of human bone marrow stem cells (hBMSCs), a micro/nano structure has been fabricated on the tantalum coating surface through the combination of anodic oxidation and plasma spraying method. The morphology, composition, and microstructure of the modified coating were comprehensively studied by employing scanning electron microscopy (SEM), X-ray diffraction (XRD) as well as transmission electron microscopy (TEM). The effects of hierarchical structures as well as micro-porous structure of tantalum coating on the behavior for human bone marrow stem cells (hBMSCs) were evaluated and compared at both cellular and molecular levels in vitro. The experimental results show that a hierarchical micro/nano structure with Ta₂O₅ nanotubes spread onto a micro-scale tantalum coating has been fabricated successfully, which is confirmed to promote cell adhesion and spreading. Besides, the hierarchical micro/nano tantalum coating can provide 1.5~2.1 times improvement in gene expression, compared with the micro-porous tantalum coating. It demonstrates that it can effectively enhance the proliferation and differentiation of hBMSCs in vitro.

摘要

近年来，钽因其耐腐蚀性和生物相容性备受关注，并已广泛应用于植入物表面改性。为了促进人骨髓干细胞（hBMSCs）的成骨分化，通过阳极氧化和等离子喷涂相结合的方法在钽涂层表面制备了微/纳米结构。采用扫描电子显微镜（SEM）、X射线衍射（XRD）以及透射电子显微镜（TEM）对改性涂层的形貌、成分和微观结构进行了全面研究。在体外细胞和分子水平上评估并比较了钽涂层的分级结构和微孔结构对人骨髓干细胞（hBMSCs）行为的影响。实验结果表明，成功制备了一种Ta₂O₅纳米管分布在微米级钽涂层上的分级微/纳米结构，该结构被证实可促进细胞黏附和铺展。此外，与微孔钽涂层相比，分级微/纳米钽涂层可使基因表达提高1.5至2.1倍。这表明它能有效增强体外hBMSCs的增殖和分化。

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