Ghosh Apurba K, Kishore Bala, Shaikh Irfan, Satyavrat Vinita, Kumar Anil, Shah Tapan, Pote Prahlad, Shinde Sandeep, Berde Yatin, Low Yen Ling, Tan Verena M H, Huynh Dieu T T
1 Institute of Child Health, Kolkata, India.
2 St Theresas Hospital, Hyderabad, India.
J Int Med Res. 2018 Jun;46(6):2186-2201. doi: 10.1177/0300060518757355. Epub 2018 Apr 3.
Objectives To evaluate the effect of oral nutritional supplementation (ONS) plus dietary counselling (DC) (intervention) versus DC alone (control) on growth and upper respiratory tract infection (URTI) in nutritionally at-risk, picky eating children in India. Methods We performed a 90-day, prospective, randomized, controlled trial. A total of 255 children aged 24-72 months with a weight-for-age z-score ≥-2 and <-1, picky eating behaviour, and acute URTI were randomized to the control (n = 128) or intervention group (n = 127). The outcomes included the change in weight-for-age z-score from days 1 to 90 and the URTI incidence. Results The mean age was 44.0 ± 14.3 months. The intervention group showed a significantly greater increase in mean weight-for-age and body mass index-for-age z-scores compared with the control group from day 10 onwards. Higher energy intake in the intervention group was observed at all follow-up visits, except for day 10. The incidence of URTI in the control group was 2.01 times higher than that in the intervention group, controlling for confounding factors. Conclusions ONS plus DC is effective for improving weight and reducing the incidence of URTI in nutritionally at-risk, picky eating children with an acute URTI episode.
目的 评估口服营养补充剂（ONS）加饮食咨询（DC）（干预组）与单纯饮食咨询（对照组）对印度营养风险高、挑食儿童生长及上呼吸道感染（URTI）的影响。方法 我们进行了一项为期90天的前瞻性随机对照试验。共有255名年龄在24至72个月、年龄别体重z评分≥-2且<-1、有挑食行为且患有急性URTI的儿童被随机分为对照组（n = 128）或干预组（n = 127）。结局指标包括第1天至第90天年龄别体重z评分的变化以及URTI发病率。结果 平均年龄为44.0±14.3个月。从第10天起，干预组的平均年龄别体重和年龄别体重指数z评分的增加幅度显著大于对照组。除第10天外，在所有随访中均观察到干预组的能量摄入量更高。在控制混杂因素后，对照组的URTI发病率比干预组高2.01倍。结论 ONS加DC对于改善营养风险高、挑食且患有急性URTI发作的儿童的体重及降低URTI发病率有效。
