Wei Guoqing, Wang Yu, Yang Guang, Wang Yi, Ju Rong
Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, PR China.
College of Medicine, Southwest Jiaotong University, Chengdu, 610031, PR China.
Theranostics. 2021 Apr 19;11(13):6370-6392. doi: 10.7150/thno.57828. eCollection 2021.
As one of the most important cancer treatment strategies, conventional chemotherapy has substantial side effects and leads easily to cancer treatment failure. Therefore, exploring and developing more efficient methods to enhance cancer chemotherapy is an urgently important problem that must be solved. With the development of nanotechnology, nanomedicine has showed a good application prospect in improving cancer chemotherapy. In this review, we aim to present a discussion on the significant research progress in nanomedicine for enhanced cancer chemotherapy. First, increased enrichment of drugs in tumor tissues relying on different targeting ligands and promoting tissue penetration are summarized. Second, specific subcellular organelle-targeted chemotherapy is discussed. Next, different combinational strategies to reverse multidrug resistance (MDR) and improve the effective intracellular concentration of therapeutics are discussed. Furthermore, the advantages of combination therapy for cancer treatment are emphasized. Finally, we discuss the major problems facing therapeutic nanomedicine for cancer chemotherapy, and propose possible future directions in this field.
作为最重要的癌症治疗策略之一，传统化疗具有严重的副作用，且容易导致癌症治疗失败。因此，探索和开发更有效的方法来增强癌症化疗效果是一个亟待解决的重要问题。随着纳米技术的发展，纳米医学在改善癌症化疗方面展现出良好的应用前景。在本综述中，我们旨在对纳米医学在增强癌症化疗方面的重大研究进展进行讨论。首先，总结了依靠不同靶向配体增加药物在肿瘤组织中的富集以及促进组织渗透的情况。其次，讨论了针对特定亚细胞器的靶向化疗。接下来，探讨了不同的联合策略以逆转多药耐药性（MDR）并提高治疗药物在细胞内的有效浓度。此外，强调了联合治疗在癌症治疗中的优势。最后，我们讨论了癌症化疗治疗性纳米医学面临的主要问题，并提出了该领域未来可能的发展方向。
