Sobaih Badr H
Department of Pediatrics, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2018 Apr;39(4):368-372. doi: 10.15537/smj.2018.4.21989.
To assess infants' cognitive function at the corrected age of 24-36 months, and to identify factors associated with adverse outcome and examine the correlation between Bayley Infants Neurodevelopmental Screener (BINS) score and Gesell Schedule of Child Development (GSCD). Methods: This retrospective study was performed on Saudi very low birth-weight (VLBW) infants born in King Khalid University Hospital, Riyadh, Saudi Arabia between 1997 and 2014 by the use of BINS as screening test and GSCD as definitive test. Results: Of 561 enrolled infants, 367 (65.4%) continued to follow-up. Three-hundred and fifteen infants (85.6%) had a normal cognitive function. In addition to lower birth weight (beta = -0.003) (p less than 0.001), male gender (OR =3.9) (p=0.001)and cerebral palsy (OR =33.9) (p less than 0.001) were the strongest factors associated with poor cognitive outcome. Approximately 75.4% of infants with normal BINS score had normal cognitive function and 7.6% of total infants had sever cognitive impairment. Conclusion: The majority of VLBW infants in our center have normal cognitive function at the corrected age of 24-36 months. Male gender, lower birth weight, and cerebral palsy are major predictors of poor outcome. The BINS scores were correlated with GSCD as a valid predictor for future developmental outcome.
评估24至36个月矫正年龄婴儿的认知功能，确定与不良结局相关的因素，并检验贝利婴儿神经发育筛查量表（BINS）得分与格塞尔儿童发育量表（GSCD）之间的相关性。方法：本回顾性研究对1997年至2014年在沙特阿拉伯利雅得哈立德国王大学医院出生的沙特超低出生体重（VLBW）婴儿进行，使用BINS作为筛查测试，GSCD作为确定性测试。结果：在561名登记婴儿中，367名（65.4%）继续接受随访。315名婴儿（85.6%）认知功能正常。除了较低的出生体重（β=-0.003）（p<0.001）外，男性（OR=3.9）（p=0.001）和脑瘫（OR=33.9）（p<0.001）是与认知不良结局相关的最强因素。BINS得分正常的婴儿中约75.4%认知功能正常，所有婴儿中有7.6%有严重认知障碍。结论：我们中心的大多数超低出生体重婴儿在24至36个月矫正年龄时认知功能正常。男性、较低的出生体重和脑瘫是不良结局的主要预测因素。BINS得分与GSCD相关，可作为未来发育结局的有效预测指标。
