Karlowicz-Bodalska Katarzyna, Han Stanislaw, Freier Julia, Smolenski Michal, Bodalska Agnieszka
Acta Pol Pharm. 2017 Mar;74(2):605-610.
Curcuma longa L. (turmeric) of ginger family (Zingiberaceae) belongs to the group of oldest cultivated spice plants in the south-east Asian countries. For many years rhizome of this plant has been used also as a safe and active drug for the treatment of various.chronic diseases, especially of diabetes mellitus (DM). The active substance of turmeric - curcumin (diferuloylmethane), possesses multiple therapeutic properties. In recent years, many detailed research (tests in vito and in vivo) along with clinical trials have revealed its very valuable biological activities related to its anti-inflammatory, antioxidant and cancer preventive properties, which are presented in numerous publications (1-6). At the molecular level it has been stated that curcumin inhibits cell proliferation, metastasis creation and apoptosis. Currently, great attention has been focused on curcumin as a blocker of TNF-s, which are the principal mediators of most inflammation-related disturbances (7). The main cause of blocking the broadly extended pharmacological and clinical investigations of curcumin is its extremely low solubility in water and in organ fluids. This feature consequently limits its systemic bioavailability and makes use of curcumin as a therapeutic remedy (to date) difficult. The primary aim of presently conducted research is to achieve increased solubilization and bioavailability of this promising nontoxic agent.
姜科姜黄属植物姜黄（Curcuma longa L.）是东南亚国家最古老的栽培香料植物之一。多年来，这种植物的根茎也被用作治疗各种慢性病，尤其是糖尿病（DM）的安全有效的药物。姜黄的活性成分姜黄素（二阿魏酰甲烷）具有多种治疗特性。近年来，许多详细的研究（体外和体内试验）以及临床试验揭示了其与抗炎、抗氧化和防癌特性相关的非常有价值的生物活性，这些在众多出版物中都有介绍（1 - 6）。在分子水平上，已经表明姜黄素可抑制细胞增殖、转移形成和凋亡。目前，姜黄素作为肿瘤坏死因子 - s的阻滞剂受到了极大关注，肿瘤坏死因子 - s是大多数炎症相关紊乱的主要介质（7）。阻碍姜黄素广泛的药理和临床研究的主要原因是其在水和体液中的溶解度极低。这一特性因此限制了其全身生物利用度，使得姜黄素作为一种治疗药物（迄今为止）难以应用。
