Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
Cell Chem Biol. 2018 Jun 21;25(6):648-658. doi: 10.1016/j.chembiol.2018.03.003. Epub 2018 Apr 5.
Cell-based drug delivery systems offer the prospect of biocompatibility, large-loading capacity, long in vivo lifespan, and active targeting of diseased sites. However, these opportunities are offset by an array of challenges, including safeguarding the integrity of the drug cargo and the cellular host, as well as ensuring that drug release occurs at the appropriate time and place. Emerging strategies that address these, and related, issues, are described herein.
基于细胞的药物传递系统具有生物相容性、大载药量、长体内寿命和对病变部位的主动靶向性等优点。然而，这些机会也带来了一系列挑战，包括保护药物货物和细胞宿主的完整性，以及确保药物在适当的时间和地点释放。本文介绍了旨在解决这些问题和相关问题的新兴策略。
