Min 蛋白震荡：细胞蛋白波自组织的一个范例。
The Min-protein oscillations in : an example of self-organized cellular protein waves.
机构信息
Theoretische Physik, Universität des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany.
Departments of Biochemistry and Theoretical Physics, NCCR Chemical Biology, University of Geneva, 1211 Geneva, Switzerland
出版信息
Philos Trans R Soc Lond B Biol Sci. 2018 May 26;373(1747). doi: 10.1098/rstb.2017.0111.
Abstract
In the rod-shaped bacterium , selection of the cell centre as the division site involves pole-to-pole oscillations of the proteins MinC, MinD and MinE. This spatio-temporal pattern emerges from interactions among the Min proteins and with the cytoplasmic membrane. Combining experimental studies and together with theoretical analysis has led to a fairly good understanding of Min-protein self-organization. In different geometries, the system can, in addition to standing waves, also produce travelling planar and spiral waves as well as coexisting stable stationary distributions. Today it stands as one of the best-studied examples of cellular self-organization of proteins.This article is part of the theme issue 'Self-organization in cell biology'.
摘要
在杆状细菌中，选择细胞中心作为分裂部位涉及到 MinC、MinD 和 MinE 蛋白的极向振荡。这种时空模式源于 Min 蛋白之间的相互作用以及与细胞质膜的相互作用。将实验研究与理论分析相结合，使人们对 Min 蛋白的自组织有了相当好的理解。在不同的几何形状下，该系统除了可以产生驻波外，还可以产生移动的平面波和螺旋波，以及共存的稳定固定分布。如今，它已成为蛋白质细胞自我组织的最佳研究实例之一。本文是“细胞生物学中的自我组织”主题特刊的一部分。
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