Neuroscience Research Institute, Peking University, Beijing, 100083, China.
Key Laboratory for Neuroscience, Ministry of Education of China, Peking University, Beijing, 100083, China.
Neurosci Bull. 2018 Oct;34(5):789-800. doi: 10.1007/s12264-018-0224-8. Epub 2018 Apr 10.
Autism spectrum disorder can be differentiated into three subtypes (aloof, passive, and active-but-odd) based on social behaviors according to the Wing Subgroups Questionnaire (WSQ). However, the correlations between the scores on some individual items and the total score are poor. In the present study, we translated the WSQ into Chinese, modified it, validated it in autistic and typically-developing Chinese children, and renamed it the Beijing Autism Subtyping Questionnaire (BASQ). Our results demonstrated that the BASQ had improved validity and reliability, and differentiated autistic children into these three subtypes more precisely. We noted that the autistic symptoms tended to be severe in the aloof, moderate in the passive, and mild in the active-but-odd subtypes. The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.
自闭症谱系障碍（autism spectrum disorder）可根据社交行为通过 Wing 亚群问卷（Wing Subgroups Questionnaire，WSQ）分为三个亚型（冷漠型、被动型和活跃但古怪型）。然而，一些单项得分与总分之间的相关性较差。在本研究中，我们将 WSQ 翻译成中文，对其进行了修改，并在自闭症和正常发育的中国儿童中进行了验证，将其重新命名为北京自闭症亚群问卷（Beijing Autism Subtyping Questionnaire，BASQ）。我们的结果表明，BASQ 具有更好的有效性和可靠性，能更准确地将自闭症儿童分为这三个亚型。我们注意到，冷漠型的自闭症症状往往更严重，被动型的症状中等，活跃但古怪型的症状则较轻。改良后的问卷可能有助于病因研究和治疗方案的选择。
