Nguyen James, Rothman Alissa, Fitzgerald Kathryn, Whetstone Anna, Syc-Mazurek Stephanie, Aquino Jannelle, Balcer Laura J, Frohman Elliot M, Frohman Teresa C, Crainiceanu Ciprian, Beier Meghan, Newsome Scott D, Calabresi Peter A, Saidha Shiv
a Department of Neurology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
b Department of Neurology , New York University Langone Medical Center , New York , NY , USA.
Curr Eye Res. 2018 Jul;43(7):941-948. doi: 10.1080/02713683.2018.1459730. Epub 2018 May 1.
To determine the relationships between visual function and ganglion cell and inner plexiform layer thickness and neuropsychological measures in multiple sclerosis (MS).
Ninety-five relapsing-remitting MS (RRMS) and 36 progressive MS patients underwent 100%-contrast visual acuity (VA), 2.5%- and 1.25%-contrast letter acuity (LA) testing, Cirrus-HD-optical coherence tomography, and neuropsychological assessments. Mixed-effects regression models were used to assess relationships.
Across the cohort, 1.25%-contrast LA was associated with Symbol Digit Modalities Test (SDMT; β = 2.17, p = 0.005) and Brief Visuospatial Memory Test-Revised (BVMT-R) total recall (TR) and delayed recall (DR) scores (β = 0.31, p < 0.001; β = 0.15, p = 0.039, respectively). 2.5%-contrast LA was associated with BVMT-R TR scores (β = 0.27, p = 0.006). In the RRMS cohort, 1.25%-contrast LA was generally more significantly associated with cognitive measures: SDMT (β = 2.97, p = 0.001) and BVMT-R TR (β = 0.32, p < 0.001) and DR (β = 0.22, p = 0.012).
This study suggests that visual pathway measures, particularly visual function measures, reflect aspects of cognitive function in MS, further supporting their roles as complementary outcomes in MS neuroprotection trials.
确定多发性硬化症（MS）患者视觉功能与神经节细胞及内网状层厚度之间的关系，以及与神经心理学指标的关系。
95例复发缓解型MS（RRMS）患者和36例进展型MS患者接受了100%对比度视力（VA）、2.5%和1.25%对比度字母视力（LA）测试、Cirrus-HD光学相干断层扫描以及神经心理学评估。采用混合效应回归模型评估相关性。
在整个队列中，1.25%对比度的LA与符号数字模式测验（SDMT；β = 2.17，p = 0.005）以及简明视觉空间记忆测验修订版（BVMT-R）的总回忆（TR）和延迟回忆（DR）得分相关（分别为β = 0.31，p < 0.001；β = 0.15，p = 0.039）。2.5%对比度的LA与BVMT-R的TR得分相关（β = 0.27，p = 0.006）。在RRMS队列中，1.25%对比度的LA通常与认知指标的相关性更强：SDMT（β = 2.97，p = 0.001）、BVMT-R的TR（β = 0.32，p < 0.001）和DR（β = 0.22，p = 0.012）。
本研究表明，视觉通路指标，尤其是视觉功能指标，反映了MS患者认知功能的某些方面，进一步支持了它们在MS神经保护试验中作为补充性结局指标的作用。
