Shackford S R, Norton C H, Ziegler M G, Wilner K D
University of California San Diego Medical Center, Department of Surgery 92103.
Ann Surg. 1988 Feb;207(2):195-200. doi: 10.1097/00000658-198802000-00014.
To determine if atrial natriuretic factor (ANF) might have a role in blood volume regulation during hypovolemia, the serum level was measured before and after hemorrhage and resuscitation (RESUS) in a porcine shock model. Hemorrhage of 40% of the blood volume produced significant (p less than 0.01) decreases in mean arterial pressure, central venous pressure, and cardiac output and a significant increase in heart rate (HR), plasma renin activity, and catecholamines (p less than 0.01). Hemorrhage was also associated with a significant increase in ANF (p less than 0.05). All parameters except HR returned to baseline values with RESUS. The rise in ANF associated with moderate hemorrhage was unexpected, but may have been due to the profound tachycardia or decreased degradation during shock. Sodium excretion and urine flow increased significantly with RESUS without an associated increase in ANF, suggesting that ANF may not be involved in the early phase of postresuscitation diuresis.
为了确定心房利钠因子（ANF）在低血容量期间的血容量调节中是否发挥作用，在猪休克模型中测量了出血及复苏前后的血清水平。失血40%的血容量会使平均动脉压、中心静脉压和心输出量显著降低（p<0.01），心率（HR）、血浆肾素活性和儿茶酚胺显著升高（p<0.01）。出血还与ANF显著升高相关（p<0.05）。除HR外，所有参数在复苏后均恢复至基线值。与中度出血相关的ANF升高出乎意料，但可能是由于严重心动过速或休克期间降解减少所致。复苏后钠排泄和尿流量显著增加，而ANF未相应增加，这表明ANF可能不参与复苏后利尿的早期阶段。
