Bie Qingli, Dong Haixin, Jin Chengqiang, Zhang Hao, Zhang Bin
Department of Laboratory Medicine, Affiliated Hospital of Jining Medical UniversityJining, Shandong, P. R. China.
Institute of Forensic Medicine and Laboratory Medicine, Jining Medical UniversityJining, Shandong, P. R. China.
Am J Transl Res. 2018 Mar 15;10(3):648-658. eCollection 2018.
15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a natural PPARγ agonist, has been investigated for over a decade. Studies have revealed that it has proapoptotic, anti-inflammatory, antiangiogenic, and anti-metastatic abilities, as well as a significant anticancer effect. However, the mechanisms underlying the actions of 15d-PGJ2 on various tumors are only partially known. In this review, we discuss the recent progress in elucidating these mechanisms. Understanding the various functions and mechanisms of 15d-PGJ2 are crucial for the development of new therapies for controlling tumor growth and providing the basis for further research.
15-脱氧-Δ12,14-前列腺素J2（15d-PGJ2）是一种天然的过氧化物酶体增殖物激活受体γ（PPARγ）激动剂，对其进行的研究已有十多年。研究表明，它具有促凋亡、抗炎、抗血管生成和抗转移能力，以及显著的抗癌作用。然而，15d-PGJ2对各种肿瘤作用的潜在机制仅部分为人所知。在本综述中，我们讨论了阐明这些机制的最新进展。了解15d-PGJ2的各种功能和机制对于开发控制肿瘤生长的新疗法以及为进一步研究提供基础至关重要。
