Department of Chemistry and the International Institute for Nanotechnology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , United States.
Department of Chemical and Biological Engineering , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , United States.
J Am Chem Soc. 2018 May 2;140(17):5678-5681. doi: 10.1021/jacs.8b02089. Epub 2018 Apr 19.
Diabetes affects millions of people worldwide and the number of diagnoses continues to climb annually. Though several effective medications and therapeutic methods have been developed to treat type 1 (T1DM) and type 2 (T2DM) diabetes mellitus, direct insulin injection remains the only effective treatment for insulin resistant (IR) diabetes patients. Here, we immobilize insulin in a crystalline mesoporous metal-organic framework (MOF), NU-1000, and obtain a high loading of ∼40 wt % in only 30 min. The acid-stable MOF capsules are found to effectively prevent insulin from degrading in the presence of stomach acid and the digestive enzyme, pepsin. Furthermore, the encapsulated insulin can be released from NU-1000 under simulated physiological conditions.
糖尿病影响着全球数百万人，其诊断数量每年仍在持续攀升。尽管已经开发出几种有效的药物和治疗方法来治疗 1 型（T1DM）和 2 型（T2DM）糖尿病，但直接胰岛素注射仍然是治疗胰岛素抵抗（IR）糖尿病患者的唯一有效方法。在这里，我们将胰岛素固定在结晶介孔金属有机骨架（MOF）NU-1000 中，仅在 30 分钟内即可实现约 40wt%的高负载量。研究发现，这种酸稳定的 MOF 胶囊可以有效地防止胰岛素在胃酸和消化酶胃蛋白酶的存在下降解。此外，包封的胰岛素可以在模拟生理条件下从 NU-1000 中释放出来。
