Cui Baiping, Zheng Yufan, Sun Lihua, Shi Ting, Shi Ziyu, Wang Lijue, Huang Guoying, Sun Ning
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University.
Yan Cheng Institute of Health Sciences, China.
Acta Cardiol Sin. 2018 Mar;34(2):115-123. doi: 10.6515/ACS.201803_34(2).20171206A.
Heart regeneration remains a critical question in current basic research and clinical practice. The adult mammalian heart exhibits a very limited regeneration capacity. In contrast, adult zebrafish and neonatal mice retain a remarkable ability of heart regeneration after damage. Understanding the mechanisms of heart regeneration would be very valuable to help design efficient treatment strategies against myocardial damage and heart failure. While inherent regeneration of the heart occurs after damage with varying efficiency among species, regeneration may also be induced exogenously. In this study, we briefly review the different approaches and current progress in improving heart regeneration.
心脏再生仍然是当前基础研究和临床实践中的一个关键问题。成年哺乳动物心脏的再生能力非常有限。相比之下，成年斑马鱼和新生小鼠在心脏受损后仍保留显著的再生能力。了解心脏再生的机制对于帮助设计针对心肌损伤和心力衰竭的有效治疗策略非常有价值。虽然心脏在受损后会发生不同效率的固有再生，但再生也可能由外源性诱导。在本研究中，我们简要回顾了改善心脏再生的不同方法和当前进展。
