全身及玻璃体内注射伏立康唑治疗静脉吸毒相关的眼内炎
Intravenous Drug Use-Associated Endophthalmitis Treated with Systemic and Intravitreal Voriconazole.
作者信息
Raevis Joseph J, Shaik Neha, Tseng Joseph
机构信息
Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York, USA.
出版信息
Case Rep Ophthalmol. 2018 Jan 5;9(1):37-42. doi: 10.1159/000485552. eCollection 2018 Jan-Apr.
PURPOSE
To report a case of intravenous (i.v.) heroin use-associated endogenous endophthalmitis caused by fungal species, and its response to intravitreal and oral voriconazole treatments.
PATIENT
A 21-year-old-female with chronic hepatitis C and i.v. heroin use presented with subacute decreased vision to hand motion in her left eye.
RESULTS
Endogenous fungal endophthalmitis caused by was confirmed by vitreous biopsy. The patient improved clinically after vitrectomy with intravitreal voriconazole and 3 weeks of oral voriconazole. The final vision was 20/60 after 6 months.
CONCLUSIONS
is a rare cause of endophthalmitis, and is often difficult to treat due to its resistance to commonly used antifungals. This case is the first report of endophthalmitis secondary to i.v. drug use.
目的
报告一例因静脉注射海洛因使用相关的由真菌引起的内源性眼内炎病例，以及其对玻璃体内注射和口服伏立康唑治疗的反应。
患者
一名21岁患有慢性丙型肝炎且有静脉注射海洛因史的女性，左眼视力亚急性下降至仅能看到手动。
结果
经玻璃体活检确诊为由真菌引起的内源性真菌性眼内炎。患者在接受玻璃体切割术联合玻璃体内注射伏立康唑及3周口服伏立康唑治疗后临床症状改善。6个月后最终视力为20/60。
结论
真菌是眼内炎的罕见病因，且由于其对常用抗真菌药物耐药，常难以治疗。该病例是首例关于静脉注射毒品继发真菌性眼内炎的报告。
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