Schneider Carole M, Hsieh City C, Sprod Lisa K, Carter Susan D, Hayward Reid
Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, CO 80639, USA. carole.schneider @unco.edu
Integr Cancer Ther. 2007 Sep;6(3):235-41. doi: 10.1177/1534735407305871.
This investigation determined the cardiopulmonary function and fatigue alterations in male cancer survivors during treatment as well as following treatment utilizing similar exercise assessment protocols and individualized, prescriptive exercise interventions. The study included 45 male cancer survivors that were referred by local oncologists. Following a comprehensive screening and physical examination, cardiovascular endurance, pulmonary function, and fatigue were assessed leading to the development of 12-week individualized exercise prescriptions and exercise interventions. The cancer survivors were divided into during treatment (DTm) and following treatment (FTm) groups. Repeated-measures analysis of variance and analyses of covariance were used to compare pre- versus postintervention and between groups. Cardiopulmonary function was maintained in the DTm, whereas the FTm showed significant reductions in resting heart rate (P < .05) with concurrent increases in predicted VO2max and time on treadmill ( P < .05) postexercise intervention. Fatigue levels did not increase in the DTm group, whereas the FTm group showed significant reductions in behavioral fatigue, affective fatigue, sensory fatigue, cognitive/mood fatigue, and total fatigue (P < .05) after the exercise intervention. The results of the current study suggest that moderate intensity, individualized, prescriptive exercise intervention maintains or improves cardiovascular and pulmonary function with concomitant reductions in fatigue in cancer survivors during and following cancer treatment. Exercise appears to be a safe, efficacious strategy for improving physical fitness in cancer survivors during and following treatment.
本研究通过使用相似的运动评估方案以及个性化的、规定性的运动干预措施，确定了男性癌症幸存者在治疗期间以及治疗后的心肺功能和疲劳变化。该研究纳入了45名由当地肿瘤学家转诊的男性癌症幸存者。在进行全面的筛查和体格检查后，对心血管耐力、肺功能和疲劳进行了评估，从而制定了为期12周的个性化运动处方和运动干预措施。癌症幸存者被分为治疗期间组（DTm）和治疗后组（FTm）。采用重复测量方差分析和协方差分析来比较干预前后以及组间的情况。DTm组的心肺功能得以维持，而FTm组在运动干预后静息心率显著降低（P < .05），同时预测的最大摄氧量和跑步机运动时间增加（P < .05）。DTm组的疲劳水平没有增加，而FTm组在运动干预后行为疲劳、情感疲劳、感觉疲劳、认知/情绪疲劳和总疲劳显著降低（P < .05）。本研究结果表明，中等强度、个性化、规定性的运动干预可维持或改善癌症幸存者在癌症治疗期间及治疗后的心血管和肺功能，同时减轻疲劳。运动似乎是改善癌症幸存者在治疗期间及治疗后身体素质的一种安全、有效的策略。
